Randomized to resistance training 72 Randomized to aerobic exercise 76

Randomized to resistance training 72 randomized to

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Randomized to resistance training 72 Randomized to aerobic exercise 76 Randomized to combination exercise 4 Lost to follow-up 0 Left for medical reasons 2 Could not be contacted 2 Unwilling to participate 5 Lost to follow-up 0 Left for medical reasons 3 Could not be contacted 2 Unwilling to participate 3 Lost to follow-up 0 Left for medical reasons 2 Could not be contacted 1 Unwilling to participate 5 Lost to follow-up 1 Left for medical reasons 3 Could not be contacted 1 Unwilling to participate 292 Eligible for baseline 2 visit 328 Eligible for baseline 1 visit 952 Eligible for run-in visits (1-6) 1282 Eligible for orientation visit 2421 Individuals screened for eligibility 37 Completed trial 68 Completed trial 69 Completed trial 71 Completed trial 41 Included in intent-to-treat analysis 41 Included in per-protocol analysis 73 Included in intent-to-treat analysis 60 Included in per-protocol analysis 13 Excluded 5 Lost to follow-up 8 Adherence < 70% 72 Included in intent-to-treat analysis 52 Included in per-protocol analysis 20 Excluded 3 Lost to follow-up 17 Adherence < 70% 76 Included in intent-to-treat analysis 62 Included in per-protocol analysis 14 Excluded 5 Lost to follow-up 9 Adherence < 70% 262 Randomized 36 Excluded 29 Met other study exclusion criteria 7 Declined or other 30 Excluded 4 Had precluding medical condition 20 Met other study exclusion criteria 2 Could not be contacted 4 Declined or other 330 Excluded 115 Could not be contacted 5 Had precluding medical condition 87 Met other study exclusion criteria 123 Declined or other 1139 Excluded 415 Declined 247 Not interested 168 Could not meet study demands 80 Not diabetic 39 Did not meet age criteria 33 Took excluded medication 171 Had medical exclusions 28 Were too active 24 Had recent weight change 10 Enrolled in other study 154 Other or not specified 185 BMI 48.0 624 Excluded 271 Had HbA 1c < 6.5% 49 Had HbA 1c > 11.0% 57 Could not be contacted 29 Had significant medical condition 132 Met other study exclusion criteria 86 Declined or other EXERCISE, HEMOGLOBIN A 1C , AND DIABETES ©2010 American Medical Association. All rights reserved. (Reprinted) JAMA, November 24, 2010—Vol 304, No. 20 2255 at unknown institution on November 23, 2010 Downloaded from
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on a DXC 600 Pro (Beckman Coulter Inc, Brea, California). Insulin was mea- sured using an immunoassay on the Siemens 2000 (Siemens, Deerfield, Illinois). Exercise testing was conducted on a treadmill (Trackmaster 425, Carefu- sion, Newton, Kansas) with respira- tory gases sampled using a True Max 2400 Metabolic Measurement Cart (ParvoMedics, Salt Lake City, Utah). Participants self-selected a walking pace and the grade increased by 2% every 2 minutes until exhaustion. The same speed was used for baseline and fol- low-up testing. Maximal estimated metabolic equivalent tasks (METs) achieved was calculated from speed and grade.
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