v Macrolides binds to cell membrane and changes protein function 1 erythromycin

V macrolides binds to cell membrane and changes

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v.Macrolides- binds to cell membrane and changes protein function1.erythromycin, azithromycin(Zithromax) and other2.uses: acute infection, acne, URI, prophylaxis before dental procedures if allergic to PCN3.SE: diarrhea, confusion, hepatotoxic4.NI: monitor LFT, take 1 hr ac or 2-3 hrs pc.vi.Tetracycline- 1.Inhibit protein synthesis of bacteria2.Use: infections, ac ne, prophylaxis for infant after delivery3.Ex. Doxycycline, tetracycline4.SE: rash, photosensitivity, be aware of potential for dental discoloration in children under 8; do not give to pregnant women( can cross placenta); stain teeth; GI SE.vii.Sulfonamides8
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1.Antagonize essential component of folic acid synthesis2.Drug: Bactrim, Septra, sulfasalazine, Sulfisoxazole3.Use: Ulcerative colitis, Crohns, otitis media, UTI4.SE: peripheral neuropathy, photosensitivity, GI upset, stomatitis, nephrotoxicity( crystalluria)5.NI: force fluids( to prevent crystalluria), I&O; do not take with cranberry juice/acidic juice; take with meals; teach pt to wear sunscreen, hats and long sleeves.viii.Antifungals- used to treat fungal infections; miconazole, nystatinix.Antiviral- tx infections caused by viruses1.Acyclovir ( zovirax)2.Amantadine- take it before flu sxs3.Retrovir/AZT: tx for HIV infectedPentamidine tx for Pneumocystic pneumonia carinii ( an AIDS opportunistic infection)4.Protease inhibitors- saquinavir, ritonavir, - block the maturation of HIV virus; used to tx HIV infections5.SE: nephrotoxic with increased BUN and Creatininex.Antituberculins- used to tx an infection caused by Mycobacteium tuberculosis1.Isoniazid( peripheral neuropathy), ethambutol( vision problems), rifampin(orangish secretions)- all hepatoxic; nephrotoxic, ototoxicc.Urinary Tract Antiinfectives ( See Urinary)i.Urinary antimicrobials- substance excreted and concentrate in urine in sufficient amt to have and antiseptic effect on urine and urinary tractii.See Bactrim, Cipro, macrodantin,1.Sulfonamides : a.Bactrim- lots of waterb.Gantrisan2.Furadantin: SE: asthma attack, diarrhea: give with food or milk, monitor pulmonary status3.Mandelamine : a.SE: Increased LFTsb.Give with cranberry juice, limit intake w alkaline foods. 4.Pyridium: ( urinary analgesic)- relieves discomfort and spasms; a.Produce a local anesthetic effect on mucosa of ureters and bladder to relieve burning, pain, urgency and frequency associated with UTIb.discolors urine reddish orange, stains.16.Anti inflammatoriesa.Antipyretic- used to reduce fevers associated with a variety of conditions; most common are aspirin and acetaminophen9
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b.Salicylates: ASA- also antiplatelet, analgesic, antipyretic, antiinflammatoryi.GI irritantii.Tinnitus- often indicates toxicityiii.Anti platelet properties; thus bleedingiv.Metabolic acidosis in overdosev.Asa: do not give to children: risk of Reyes syndrome in children with viral infections.
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  • Spring '14
  • ArunL.Jadhav
  • i., Angiotensin II receptor antagonist, Angiotensin receptor

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