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Lecture_6

42 types of t cells glycoprotein expressed helper t h

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42 Types of T cells Glycoprotein expressed Helper (T H 1 and T H 2) CD4 Cytotoxic (Tc) CD8 Memory CD4 or 8 Regulatory (suppressor) CD4 Natural killer T cells None T H 1 stimulate Tc cells T H 2 stimulate B cells
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43
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44 Natural Killer Cells Natural Virus infected cell or tumor cell Granules full of enzymes
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45 Clone A clone is a group of identical cells descended from a common ancestor. A clone of T cells or B cells will recognize the same antigenic determinant . The speciFcity of a T or B cell is determined by its receptor for the Ag. Clones of parent cells
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46 How does the body stop T cells from attacking itself? T cell clones undergo positive and negative selection
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47 T cells undergo positive and negative selection in the thymus
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48 T cell receptors can only recognize Ag bound to MHC proteins Virus infected target cell TCR CD8 MHC I Viral Ag Tc cell
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49 Binding of TCR with Ag + MHC I protein on a Virus-infected cell leads to cell death
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50 Intracellular vs extracellular antigens APC = macrophages, dendritic cells & B cells
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51 Cytotoxic T cell killing movie http://highered.mcgraw-hill.com/olc/dl/120110/micro34.swf Cell Mediated Immune response movie http://www.youtube.com/watch? 4&index=3
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52 Comparison of Cytotoxic T Cells and Natural Killer Cells Cytotoxic T Cells Natural Killer Cells CD8, T cell receptor No Require clonal activation No 7-10 days to be fully activated Act immediately SpeciFc for antigen No Immunological memory No
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42 Types of T cells Glycoprotein expressed Helper T H 1 and...

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