ELIQUIS INHIBITS FACTOR XA AND PROTHROMBINASE ACTIVITY WITHOUT REQUIRING

Eliquis inhibits factor xa and prothrombinase

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ELIQUIS INHIBITS FACTOR XA AND PROTHROMBINASE ACTIVITY WITHOUT REQUIRING ANTITHROMBIN III FOR ANTITHROMBOTIC ACTIVITY (FALA, 2013)
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PHARMACODYNAMIC PROPERTIES ELIQUIS IS TAKEN ORALLY TRADITIONALLY. IT CAN BE SUPPLIED INTRAVENOUSLY BUT IS NOT RECOMMENDED FOR MAINTENANCE THERAPY DUE TO NO REVERSAL AGENTS. IT COMES IN A 2.5 MG SMALL ROUND YELLOW PILL AND THE 5 MG IS AN OVAL PINK PILL. THE BASE IS MADE UP FOR WHITE TO PALE/YELLOW POWDER. ELIQUIS DOES NOT IONIZE, IS AN AQUEOUS SOLUBLE AND IS AT PHYSIOLOGICAL PH (1.2-6.8).
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PHARMACODYNAMIC PROPERTIES ELIQUIS WORKS BY INHIBITING FXA AND PROLONGS CLOTTING (ELIQUIS MEDICATION DATA SHEET, 2019). ACTIVATED PARTIAL THROMBOPLASTIN TIME (APTT), INR, AND PROTHROMBIN TIMES (PT) COAGULATIONS STUDIES WILL BE OBSERVED TO ACHIEVE A THERAPEUTIC DOSE. UNLIKE WARFARIN, MINIMAL CHANGES WILL BE SEEN ONCE THERAPEUTIC BUT NOT SIGNIFICANT TO REQUIRE SERIAL MONITORING.
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ABSORPTION THE BIOAVAILABILITY OF ELIQUIS IS APPROXIMATELY 50% FOR DOSES UP TO 10 MG. FOOD DOES NOT INTERACT WITH THE BIOAVAILABILITY SUCH AS LEAFY GREENS DOES WITH WARFARIN. ELIQUIS APPEARS 3-4 HOURS AFTER ORAL DOSE. IT IS ABSORBED THROUGHOUT GI TRACT WITH THE DISTAL SMALL BOWEL AND ASCENDING COLON SUPPLYING ABOUT 55% OF ABSORPTION (ELIQUIS MEDICATION DATA SHEET, 2019).
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DISTRIBUTION ELIQUIS IS DISTRIBUTED THROUGH THE BODY BY PLASMA PROTEIN BINDING PROTEINS; IN HUMANS THIS IS 87% OF THE THE VOLUME OF DISTRIBUTION AT APPROXIMATELY 21 LITERS (ELIQUIS MEDICATION DATA SHEET, 2019).
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METABOLISM DURING THE DRUG METABOLISM PROCESS, 25% OF ELIQUIS IS EXCRETED THROUGH URINE AND FECES (ELIQUIS MEDICATION DATA SHEET, 2019).
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