Nelson hd huffman lh fu r et al ann intern med 2005

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Nelson HD, Huffman LH, Fu R, et al. Ann Intern Med 2005 Sep 6;143(5):362-79. PMID: 16144895. U.S. Preventive Services Task Force. Ann Intern Med 2005 Sep 6;143(5):355-61. PMID: 16144894.
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The ability of providers to accurately determine a family history that indicates increased risk is needed for BRCA mutation tests and other predictive genetic tests to be useful. Sometimes it is difficult for people to accurately recall whether their relatives have a medical condition. The sensitivity and specificity of family history self- reports are important in determining overall usefulness of predictive genetic testing. Illustrative Example 3: BRCA Mutation Testing (2 of 2) Jonas DE, Wilt TJ, Taylor BC, et al. Challenges in and principles for conducting systematic reviews of genetic tests used as predictive indicators. In: Methods guide for medical test reviews. Available at . Nelson HD, Huffman LH, Fu R, et al. Ann Intern Med 2005 Sep 6;143(5):362-79. PMID: 16144895.
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The general principles for evaluating genetic tests are similar to prognostic or predictive tests, but differences exist in their application and relevance. A clearly defined clinical scenario and analytic framework are important for evaluating any test. Organizing frameworks such as the ACCE model ( a nalytic validity, c linical validity, c linical utility, and e thical, legal, and social implications) and analytic frameworks are useful for evaluating genetic tests. Preanalytic, analytic, and postanalytic factors should be considered when constructing an analytic framework. Predictive genetic tests generally have a time lag between testing and clinically important events. Key Messages (1 of 2) Jonas DE, Wilt TJ, Taylor BC, et al. Challenges in and principles for conducting systematic reviews of genetic tests used as predictive indicators. In: Methods guide for medical test reviews. Available at .
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Published information on the analytic validity of genetic tests may be difficult to locate —W eb sites and gray literature may be important sources. When clinical factors associated with risk are well known, genetic tests should be evaluated for added value. For genome-wide association studies, it should be determined whether the association has been validated in multiple studies to minimize confounding and publication bias and whether appropriate adjustments for multiple comparisons were used. Key Messages (2 of 2) Jonas DE, Wilt TJ, Taylor BC, et al. Challenges in and principles for conducting systematic reviews of genetic tests used as predictive indicators. In: Methods guide for medical test reviews. Available at .
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1. Reviewers should assess the added value of using genetic testing along with which of the following: i. Known risk factors ii. Age, sex, hypertension, etc.
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