The results indicate gingipains is the main cause of

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caused the animals to develop signs of Alzheimer’s. The results indicate gingipains is the “main cause of Alzheimer’s disease,” study coauthor Steve Dominy, a neurologist at Cortexyme, Inc., a company developing treatments for the disease, tells Newsweek . The new study is one of a growing number that suggest microbes play a role in Alzheimer’s disease. See “ Do Microbes Trigger Alzheimer’s Disease? “I'm fully on board with the idea that this microbe could be a contributing factor. I'm much less convinced that [it] causes Alzheimer’s disease,” Robert Moir, a neurobiologist at Massachusetts General Hospital in Boston who was not involved in the study, tells Science . In the study, Dominy and his colleagues swabbed P. gingivalis onto the gums of healthy mice every other day for 6 weeks. The bacterium took hold, and the team later detected it in the mice’s brains, where they also found dying neurons and higher levels of β-amyloid protein than in control animals, indicating the infected animals had developed signs of Alzheimer’s disease. In cell cultures, different forms of the gingipain enzyme damaged tau, another protein associated with Alzheimer’s, and that damage may cause tau to develop into tangles, which are another indicator or Alzheimer’s neurodegeneration, the researchers found in additional experiments. The team also gave the mice a drug that bound to the gingipain enzyme. The drug cleared the infection from the animals’ brains and reduced β-amyloid production and neurodegeneration. The study “is clearly very comprehensively approached,” James Noble, a neurologist at Columbia University who has studied the link between periodontal disease and Alzheimer’s but was not involved in the new work, tells Science. “These are strange ideas, but they seem to be getting some traction.”
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  • Summer '18
  • Pisueña
  • Bacteria, Microorganism, Gingiva, Periodontitis

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