caused the animals to develop signs of Alzheimer’s. The results indicate gingipains is the “main cause of Alzheimer’s disease,” study coauthor Steve Dominy, a neurologist at Cortexyme, Inc., a company developing treatments for the disease, tells Newsweek. The new study is one of a growing number that suggest microbes play a role in Alzheimer’s disease. See “Do Microbes Trigger Alzheimer’s Disease?”“I'm fully on board with the idea that this microbe could be a contributing factor. I'm much less convinced that [it] causes Alzheimer’s disease,” Robert Moir, a neurobiologist at Massachusetts General Hospital in Boston who was not involved in the study, tells Science. In the study, Dominy and his colleagues swabbed P. gingivalis onto the gums of healthy mice every other day for 6 weeks. The bacterium took hold, and the team later detected it in the mice’s brains, where theyalso found dying neurons and higher levels of β-amyloid protein than in control animals, indicating the infected animals had developed signs of Alzheimer’s disease. In cell cultures, different forms of the gingipain enzyme damaged tau, another protein associated with Alzheimer’s, and that damage may cause tau to develop into tangles, which are another indicator or Alzheimer’s neurodegeneration, the researchers found in additional experiments. The team also gave the mice a drug that bound to the gingipain enzyme. The drug cleared the infection from the animals’ brains and reduced β-amyloid production and neurodegeneration.The study “is clearly very comprehensively approached,” James Noble, a neurologist at Columbia University who has studied the link between periodontal disease and Alzheimer’s but was not involved inthe new work, tells Science. “These are strange ideas, but they seem to be getting some traction.”
As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.
Temple University Fox School of Business ‘17, Course Hero Intern
I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.
University of Pennsylvania ‘17, Course Hero Intern
The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.