PathophysI_MDO_October1_2012_CaseDiscussion_Post (1)

Secondary causes have been excluded presence of

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secondary causes have been excluded Presence of polycystic ovaries is a sign; is a nonspecific finding Etiology Selective insulin resistance
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PCOS: Clinical Manifestations / Course Specific to PCOS Hirsutism, enlarged ovaries, infertility, amenorrhea, obesity, dysmenorrhea, persistent anovulation Chronic anovulation, obesity, hyperinsulinemia, and decreased sex hormone binding globulin all associated with endometrial cancer Insulin resistance and associated conditions
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Acanthosis Nigricans
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http://www.accessmedicine.com/popup.aspx?aID=3157181
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http://www.accessmedicine.com/popup.aspx?aID=3157105
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http://www.accessmedicine.com/popup.aspx?aID=3157066 PCOS - Pathophysiology
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Dysmenorrhea Definition Pain, typically cramping in character, in the lower abdominal region Occurs in the days just before and during menstrual flow Contributing factors (vs. risk factors) Clinical manifestations / course Accompanying symptoms may include: sweating, weakness and fatigue, insomnia, nausea, vomiting, diarrhea, back pain, headache, dizziness, syncope
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Dysmenorrhea - Pathophysiology Excessive endometrial contraction Ischemia Stimulates uterine pain fibers Excessive production of prostaglandin production (PGF2α) by secretory endometrium of the uterus
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Endometriosis Definition Chronic, recurring disease wherein there is a presence of endometrial tissue located outside of the uterine cavity; most commonly in the peritoneal cavity Risk factors
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