Drug and food interactions o Cationic compounds o Absorption reduced by

Drug and food interactions o cationic compounds o

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Drug and food interactionsoCationic compoundsoAbsorption reduced by:Aluminum antacidsMagnesium antacidsIron saltsZinc saltsSucralfateMilk and dairy products oElevation of drug levelsTheophylline (used for asthma)
Antibiotics and Anti-infective And (an anticoagulant)Tinidazole (an antifungal drug) ~ A lot of food and drug interaction, IMPORTANT TO KNOW all of these cationic compounds can interfere with the absorption of the ciprofloxacin so these agents should be taken at least 6 hours before Cipro or 2 hours after. Milk and dairy products teach the pt not to consume cause its going to reduce absorption of the Cipro, drug effects: drug to drug interactions, elevation of drug levels can occur with these drugs when taken with Cipro. Cipro can cause toxicity, if a pt was taken walfarin (coagulant) can be at risk of bleeding when taking Cipro as well. Theres quite of few drug to drug and food interactions. Metraonidazole [Flagyl]BactericidalUsesoProtozoal infectionsoInfections caused by obligate anaerobes oHelicobacter pylorioCDIAdverse effectsoNeurotoxicityoAllergyoSuperinfection~New class: Common drug, bactericidal so its going to kill that bacteria. Going to be used for protozoal type infection. This is goin to be drugs that are caused by anaerobes, pathogens such as H. pylori and C diff infections. It is actually the drug of choice of C. diff. Also drug of choice forbacterial vaginosis, so its also therapeutic for that bug it also can be given prophylaxis to help prevent an infection and reduce the risk of infection. A surgery that might deal with anaerobes can be like colon rectal surgery, abdominal surgery, or gin surgeries. Now the pt needs to be made aware they shouldn’t’ take alcohol with this drug bc risk of severe nausea and vomiting tisgood to take this drug with food bc it leaves a bitter taste. There is a risk of neurotoxicity, allergies, or super infection. Major Groups of Antifungal AgentsDrugs for systemic mycoses/ infectionsDrugs for superficial mycoses/ infectionsNote: a few drugs are used for both ~Antifungal another class, there is antifungals that can be applied topically, orally, IV all types of different types of infections. Some drugs can be given to treat both systemic, fungal infection orone that’s on the skin. Systemic MycosesTreatment can be difficultInfections often resist treatmentTreatment may require prolonged therapy with drugs that frequently prove toxic
Antibiotics and Anti-infective ~Difficult to treat, they might require prolonged therapy and drugs for systemic fungal mucosis is opportunistic, immunocompromised host, such as a pt with a HIV infection. The nonopporutnistic can occur in any host, you can see all of the diff fungal infections there Drugs for Systemic MycosesOpportunisticoImmunocompromised hostCandidiasis, aspergillosis, cryptococcosis, mucormycosisNonopportunisticoCan occur in any host Sporotrichosis, blastomycosis, histoplasmosis, coccidioidomycosis Amphotericin B

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