Timemins Figure 3 a Effect of PEG 1500 on the release profile ofTSC in aqueous

Timemins figure 3 a effect of peg 1500 on the release

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Time(mins) Figure 3 (a). Effect of PEG 1500 on the release profile ofTSC in aqueous media (b) Effect of HPMC I 5cps on PEG 4000 based suppositories in aqueous and buffer media Conclusion The experiment indicates that it is possible to design lipid based suppositories utilizing PEG and HPMC 15 cps as the release modifiers. PEGsof low 35 molecular weight can accentuate drug release by preferential soiubulization whereas HPMC 15 cps can modulate the release by gel formation and erosion. However, in vivo experimentation is an imperative in this regard to assess the performance of the dosage form environment. in fluctuating biological REFERENCES L Schniitt, M. and Cuentert, T.W. 1990. Influence of hydrophilicity of suppository bases on rectal absorption of carprofent, a lipophilic non-steroidal anti-inflammatory drug. J. Phann. Sci.79, 35'7 -363. 2. De Boer, A.G., Moolenaar,F., De lrede, L.G. and Breimer, D.D. 2000. Rectal drug administration: clinical pharmacokinetic considerations. Clin. Pharrutcokinet. 7, 285-3 l l. Realdon, N., Ragazzi, E. and Ragazzi, E. 2000. Effect of drug solubility on the in virro availability rate from suppositories with lipophilic excipients.Phanrutzie 55, 372- 311. Ermis, D. and Tarimci, N. 1995. Ketoprofen sustained- release suppositories containing hydroxypropylmethyl- cellulose pthalate in polyethylene glycol bases. Int. J. Pharm. .lcl. I13, 65-71 . Bornschein, M., Hoffman, K. and Voigt, R. 1985. Entwicklung und gegenwartiger Stand der methoden zur bestimmung der in vitro-a5zneistoffverfugbarkeit von suppositorien. Pharmazie 40, 445-449. Koch, H.P., Klissenbauer, C., Ritzinger, A. and Wallentin, A. 1987. ln vitro untersuchungen der wirkstoffliberation aus suppositorien nach dem drehkolbenverfahren. P harmozie 42, 169-t72. Lordi, N.G. 1991. Sustained Release Dosage Form. In: The Theory and Practice of lndustrial Pharmacy (Iachman L, HA Liberman and JL Kanig Eds.) 2 nd ed, [-ea & Fabiger, Philadelphia, p. 453. Craig, D.Q.M. 1993. Polyethylene glycol and drug release. Drug Dev. Ind. Pharn.2l,45-49 Boza, A., Caraballo, I., Alvarez-Fuentes, J. and Rabasco, A.M. 1999. Evaluation of Eudragit @ RS-PO and [email protected] 100 matrices for the controlled release of lobenzarit disodium. Drug Dev. Ind. PharnL25,229-233. Talukder, M.M., Michoel, A., Rhombaut, P. and Kinget, R. 1996. Comparative study of Xanthun gum and hydroxypropylmethyl cellulose as matrices for controlled- release drug delivery I. Compaction and in vitro drug release behaviour. Int. J. Pharm. 129, 231 -241. 100 BO o ^ ^ ( , , o u (g I 0) tE AA s T v 20 o. 7. o 10. Time(mins) ---r-F -SA --.rF -SA-P 2 ---.-F -SA-P l
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