Timemins figure 3 a effect of peg 1500 on the release

Time(mins)
Figure 3 (a). Effect of PEG 1500 on the release profile ofTSC in
aqueous media (b) Effect of HPMC I 5cps on PEG 4000 based
suppositories in aqueous and buffer media
Conclusion
The experiment indicates that it is possible to
design
lipid based suppositories
utilizing PEG and
HPMC 15 cps as the release modifiers. PEGsof low
35
molecular weight can accentuate drug release by
preferential soiubulization whereas HPMC
15 cps
can modulate the release by gel formation and
erosion. However, in vivo experimentation is an
imperative in this regard to assess the performance of
the dosage form
environment.
in
fluctuating
biological
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100
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