IV medication administration flow rate & dilution: 4 mg, 2 mL, IV Push, q6H; No single I.V. dose should exceed 16 mg due to the risk of QT-interval prolongation. If precipitate is noted in vial, shake vigorously until dissolved. Dilute drug in 50 mL of D5W injection or NSS for injection. Drug is stable for up to 48 hours after dilution in D5W, 5% dextrose in half-NSS for injection, 5% dextrose in NSS, and 3% sodium chloride solution for injection. Infuse over 15 minutes.
CLIENT MEDICATION FORM Drug-herb: Horehound: May enhance serotonergic effects. Discourage use together. St. John’s wort: May decrease ondansetron serum concentration. Consider therapy modification. Antidote (include dosage, route, & frequency): No specific antidote for ondansetron overdose; clients should be managed with appropriate supportive therapy. Uses/Indications (individualize for client): Use: To prevent nausea and vomiting. Adjust-a-dose (for all indications): For client with nausea and vomiting give tablet 1 hour before induction of anesthesia. Nursing Implications (including client teaching): Drug may increase the risk of prolonged QT interval and torsades de pointes (a potentially fatal heart rhythm). Monitor ECG in clients with congenital long QT syndrome, in those with HF or bradyarrhythmias, and in those taking other medications that can prolong the QT interval. Correct electrolyte abnormalities (hypokalemia or hypomagnesemia) before infusing drug. Monitor LFT results. Don’t exceed 8 mg in clients with hepatic impairment. Caution client to contact health care provider immediately if he experiences signs and symptoms of abnormal HR or rhythm, such as palpitations, dyspnea, or dizziness. Patient Teaching: Tell client that an ECG may be necessary to monitor HR and rhythm. Instruct client to immediately report difficulty breathing after drug administration. Tell client receiving drug I.V. to report discomfort at insertion site. Tell client taking ODTs to open blister just before use by peeling backing off and not by pushing through foil blister, and tell him that taking it with liquid isn’t required. Teach client to place ODTs or film on tongue, allow to dissolve, then swallow with saliva. Mechanisms of Action: Blocks serotonin receptors centrally in the chemoreceptor zone and peripherally at vagal nerve terminals in the intestine. The action reduces bausea anf vomiting by preventing serotonin release in the small intestine and by blocking signals to the CNS. Ondansteron may also bind to other serotonin receptors and to mu-opioid receptors.
CLIENT MEDICATION FORM Trade & Generic Names Haloperidol, Haldol Pharmacokinetics (absorption, [onset, peak, duration], distribution, metabolism, excretion) Absorption : Well absorbed following PO/IM administration. Decanoate salt is slowly absorbed and has a long duration of action.
You've reached the end of your free preview.
Want to read all 29 pages?
- Fall '19
- Pharmacology, Sodium, Morphine, Use