Copyright 2017 Wolters Kluwer All Rights Reserved Action of Skeletal Muscle

Copyright 2017 wolters kluwer all rights reserved

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Copyright © 2017 Wolters Kluwer • All Rights Reserved Action of Skeletal Muscle Relaxants Action of Skeletal Muscle Relaxants Most Relaxants Work in the brain and spinal cord Interfere with cycle of muscle spasm and pain Botulinum Toxins and Dantrolene Enter muscle fibers directly
Copyright © 2017 Wolters Kluwer • All Rights Reserved Action of Centrally Acting Skeletal Muscle Relaxants Action of Centrally Acting Skeletal Muscle Relaxants Work in the upper levels of the CNS to interfere with the reflexes causing the muscle spasm Possible depression anticipated with their use Lyse or Destroy Spasm Often referred to as spasmolytics
Copyright © 2017 Wolters Kluwer • All Rights Reserved Centrally-Acting Skeletal Muscle Relaxants Centrally-Acting Skeletal Muscle Relaxants Actions Exact mechanism of action is not known Thought to involve action in the upper or spinal interneurons Indications Alleviation of signs and symptoms of spasticity; use in spinal cord injuries or diseases Pharmacokinetics Rapidly absorbed and metabolized in the liver Excreted in the urine
Copyright © 2017 Wolters Kluwer • All Rights Reserved Centrally-Acting Skeletal Muscle Relaxants (cont.) Centrally-Acting Skeletal Muscle Relaxants (cont.) Adverse Reactions Drowsiness Fatigue Weakness Confusion Headache Nausea
Copyright © 2017 Wolters Kluwer • All Rights Reserved Centrally-Acting Skeletal Muscle Relaxants (cont.) Centrally-Acting Skeletal Muscle Relaxants (cont.) Adverse Reactions (cont.) Dry mouth Hypotension Drug-to-Drug Interactions CNS depressants
Copyright © 2017 Wolters Kluwer • All Rights Reserved Centrally-Acting Skeletal Muscle Relaxants (cont.) Centrally-Acting Skeletal Muscle Relaxants (cont.) Contraindications Known allergy Rheumatic disorders Cautions Epilepsy Cardiac dysfunction Conditions marked by muscle weakness
Copyright © 2017 Wolters Kluwer • All Rights Reserved

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