Acknowledgment the authors are thankful to swati

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Acknowledgment The authors are thankful to Swati Srivastava (Boston, USA) for her assistance throughout all aspects of our study and for help in writing the manuscript. Authors contributions: Conceptualization, A.K.V., A.S. and C.C., software (designed the CRISPR/Cas9 representative figure) , A.K.V. and A.T.; Data Curation, A.K.V., A.T. E.L., C.M, G.N.C, S.G. and T.G.; Writing Original Draft Preparation, A.K.V.; Writing Review & Editing, A.T. E.L., C.M, G.N.C, S.G. and T.G.; final approval of the version to be published, E.L. and C.C.; overall guarantor of the manuscript, C.C. All authors approved the manuscript. Funding: This research did not receive any external grant support Conflict of interest: Carlo Catassi is a scientific consultant to Dr. Schär and Takeda, all other authors declare no conflicts of interest. Preprints () | NOT PEER-REVIEWED | Posted: 21 February 2020 doi:10.20944/preprints202002.0296.v1