Copyright 2014 Wolters Kluwer Health Lippincott Williams Wilkins NSAIDs Actions

Copyright 2014 wolters kluwer health lippincott

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Copyright © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins NSAIDs: Actions and Uses NSAIDs: Actions and Uses Exact mechanism of action unknown; thought to work by inhibiting action of enzyme cyclooxygenase responsible for prostaglandin synthesis; NSAIDs inhibit two related enzymes Inhibit activity of cyclooxygenase-1 (COX-1): Enzyme helps to maintain the stomach lining Inhibit activity of cyclooxygenase-2 (COX-2): Enzyme triggers pain and inflammation
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Copyright © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins NSAIDs: Actions and Uses (cont.) NSAIDs: Actions and Uses (cont.) Ibuprofen and naproxen: Block COX-2, produces pain relief; inhibit COX-1, causes adverse reactions including unwanted GI reactions such as stomach irritation and ulcers Celecoxib: Inhibits only COX-2; less potential for GI adverse reactions Used for osteoarthritis, rheumatoid arthritis, and other musculoskeletal disorders; mild to moderate pain; primary dysmenorrhea; fever reduction
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Copyright © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins NSAIDs: Adverse Reactions NSAIDs: Adverse Reactions Gastrointestinal system reactions Nausea, vomiting, dyspepsia, diarrhea, constipation, epigastric pain, indigestion, abdominal distress or discomfort, intestinal ulceration, stomatitis, jaundice, bloating, anorexia, dry mouth
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Copyright © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins NSAIDs: Adverse Reactions (cont.) NSAIDs: Adverse Reactions (cont.) Central nervous system reactions Anxiety, lightheadedness, vertigo, headache, drowsiness, somnolence, insomnia, confusion, depression, stroke, psychic disturbances Cardiovascular reactions Congestive heart failure, decrease or increase in blood pressure, cardiac arrhythmias, myocardial infarction
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Copyright © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins NSAIDs: Adverse Reactions (cont.) NSAIDs: Adverse Reactions (cont.) Renal reactions Hematuria, cystitis, elevated blood urea nitrogen, polyuria, dysuria, oliguria, acute renal failure in those with impaired renal function Sensory reactions Blurred or diminished vision, diplopia, swollen or irritated eyes, photophobia, reversible loss of color vision, tinnitus, taste change, rhinitis
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Copyright © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins NSAIDs: Adverse Reactions (cont.) NSAIDs: Adverse Reactions (cont.) Hematologic reactions Neutropenia, eosinophilia, leukopenia, pancytopenia, thrombocytopenia, agranulocytosis, aplastic anemia Skin reactions Rash, erythema, irritation, skin eruptions, exfoliative dermatitis, Stevens-Johnson syndrome, ecchymosis, purpura
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Copyright © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins NSAIDs: Adverse Reactions (cont.) NSAIDs: Adverse Reactions (cont.) Metabolic/endocrine reactions Decreased appetite, weight increase or decrease, hyperglycemia or hypoglycemia, flushing, sweating, menstrual disorders, vaginal bleeding Other Thirst, fever, chills, vaginitis
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Copyright © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins NSAIDs: Contraindications NSAIDs: Contraindications Cross-sensitivity, if allergic to one NSAID, there is increased risk of allergic reaction to others; hypersensitivity to aspirin; during third trimester of pregnancy and lactation Ibuprofen: Hypertension, peptic ulceration, or GI bleeding Celecoxib: Allergic to sulfonamides, or history of cardiac disease or stroke
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  • Non-steroidal anti-inflammatory drug, Adverse drug reaction, Wolters Kluwer Health, Lippincott Williams & Wilkins

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