active and in active conformations exist in equilibrium Histamine agonist

Active and in active conformations exist in

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active and in-active conformations exist in equilibriumHistamineagonistactive > inactiveAnti-histamineinverse agonistinactive > activeAdrenergic Agonistsoβ-adrenergic antagonists (β-blockers)MOAblock β1 receptors on the ciliary bodyDecrease production of aqueous humorEx: Timololoα2-adrenergic agonistsMOAactivate presynaptic α2 receptorsdecrease NT releaseDecrease production of aqueous humorEx: BrimonidineCholinergic AgentsoMOAdirect agonists or AChE inhibitorsoActivate muscarinic receptors on iris and ciliary bodycontraction (Miosis)enlarging angleincreased drainageoIncrease drainage of aqueous humoroEx: Pilocarpine—agonistProstaglandinsanalogs of F2αoMOAremodeling of extracellular matrixoIncreased drainage of aqueous humoroEx: LatanoprostCarbonic Anhydrase InhibitorsoMOAcarbonic anhydrase catalyzes the formation of carbonic acid
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obicarbonate is required for production of aqueous humoro↓H2CO3leads to ↓ HCO3-and ↓ aqueous humoroExample: Brinzolamide
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  • Spring '18
  • Neurotransmitter, ciliary processes, corneaouter covering, Pharmacology of Ophthalmic and Otic Disorders

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