Suppressing the transmission of impulses from one nerve to the next Third they

Suppressing the transmission of impulses from one

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seizure discharge from its origin. Suppressing the transmission of impulses from one nerve to the next. Third, they decrease the speed of nerve impulse conduction within a given neuron. Less understood are the mechanisms that involve drug effects outside the neuron. Some drugs may indirectly affect seizure foci in the brain by altering blood supply to these areas. Some drugs work by enhancing the inhibitory neurotransmitter GABA. GABA regulates neuron excitability in the brain. Low levels of GABA are associated with seizures. Antiepileptic drugs increase GABA levels to the normal range, and thus reduce the potential for seizures. The overall effect is that antiepileptics stabilize neurons and keep them from becoming hyperexcited and generating excessive nerve impulses to adjacent neurons.
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ANTI PARKINSON DRUGS Monoamine Oxidase Inhibitors Name of Drug (SELEGILINE AND RASAGILINE) MAO-B Enzyme monoamine oxidase causes the breakdown of catecholamines (dopamine, norepinephrine, and epinephrine) in the body. Two subclasses of MAO in the body: MAO-A and MAO-B. Nonselective MAOIs were used but interacted w/ Tyramine-containing foods (cheese, wine, beer, yogurt) which inhibit activity against MAO-A. aka The “Cheese Effect” resulting in severe hypertension. Use of a selective MAO-B inhibitor called Selegiline is much LESS likely to inhibit the cheese effect unless it is given in high doses (over 10 mg). Approved for use w/ levodopa. Rasagiline is also a MAO-B inhibitor and it is approved to be given once daily as mono- therapy in the early stages of the disease, as well as in combination with other drugs in the advanced stages. The MAO enzymes are widely distributed throughout the body with the highest concentrations found in the liver, kidney, stomach, intestinal wall, and brain. Most MAO-B occurs in the brain. The primary role of MAO enzymes is the breakdown of catecholamines, such as dopamine, epipephrine, and norepinephrine. Giving a MAO-B inhibitor such as selegiline or rasagiline causes an increase in the level of dopaminergic stimulation in the CNS. This helps to counter the dopaminergic deficiency seen in Parkinson’s disease. Administration of selegiline can also allow the dose of levodopa to be reduced. These drugs are currently approved for use in combination with carbidopa-levidopa. They are adjunctive drugs used when a patient’s response to levodopa is fluctuating. They may also be somewhat beneficial as a prophylactic drug to delay reduction in a patient’s response to levodopa. Studies have shown that selegiline-treated patients required levodopa therapy approx. 1.8 times later than control patients. Do not take with meperidine – due to delirium, muscle rigidity, hyperpyrexia, and hyperirritability. (amantadine) Dopamine Modulator Only one drug is currently known to function as a dopamine modulator – amantadine. It was originally used for treating influenza.
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  • Winter '16
  • Neurotransmitter, dopamine receptor agonists, dopamine replacement drugs

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