MICRO
KIDNEY.pptx

Most common systemic disease associated with

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MOST COMMON SYSTEMIC DISEASE ASSOCIATED WITH NEPHROTIC SYNDROME IS DIABETES MELLITUS. 111
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SIX GLOMERULONEPHRITIS ACCOUNTS FOR > 90% CASES OF NEPHROTIC SYNDROME: MINIMAL CHANGE DISEASE FOCAL AND SEGMENTAL GLOMERULOSCLEROSIS MEMBRANOUS GLOMERULOPATHY MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS DIABETIC NEPHROPATHY AMYLOIDOSIS 112
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CLINICAL FEATURE OF MINIMAL CHANGE GLOMERULONEPHRITIS ARE ALL EXCEPT - (AI 96) A) HYPERTENSION B) EDEMA C) SELECTIVE PROTEINURIA D) FEVER 114
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MINIMAL CHANGE GLOMERULONEPHRITIS MINIMAL CHANGE DISEASE OR GLOMERULONEPHRITIS IS THE MOST COMMON CAUSE OF NEPHROTIC SYNDROME. THE UNIQUE FEATURE OF PROTEINURIA IN MINIMAL CHANGE DISEASE IS THAT IT IS - SELECTIVE PROTEINURIA. THE PROTEINURIA IN MINIMAL CHANGE DISEASE IS HIGHLY SELECTIVE, MOST OF THE PROTEIN CONSISTS OF ALBUMIN ”. NOTE THAT PROTEINURIA IN NEPHROTIC SYNDROME CAUSED DUE TO MEMBRANOUS GLOMERULONEPHRITIS IS NONSELECTIVE PROTEINURIA. 115
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CLINICAL FEATURE OF MINIMAL CHANGE GLOMERULONEPHRITIS ARE ALL EXCEPT - (AI 96) A) HYPERTENSION B) EDEMA C) SELECTIVE PROTEINURIA D) FEVER ANS. IS ‘A’ I.E., HYPERTENSION [REF: HARRISON 18,H/E P. 2345, 2346; 17VE P. 1790; NELSON 17H/E P. 1754] 116
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A 7 YEAR OLD BOY PRESENTED WITH GENERALIZED EDEMA. URINE EXAMINATION REVEALED MARKED ALBUMINURIA. SERUM BIOCHEMICAL EXAMINATIONS SHOWED HYPOALBUMINAEMIA WITH HYPERLIPIDEMIA. KIDNEY BIOPSY WAS UNDERTAKEN. ON LIGHT MICROSCOPIC EXAMINATION, THE KIDNEY APPEARED NORMAL. ELECTRON MICROSCOPIC EXAMINATION IS MOST LIKELY TO REVEAL - (AIIMS NOV 03) A) FUSION OF FOOT PROCESSES OF THE GLOMERULAR EPITHELIAL CELLS B) RAREFACTION OF GLOMERULAR BASEMENT MEMBRANE C) DEPOSITION OF ELECTRON DENSE MATERIAL IN THE BASEMENT MEMBRANE D) THIN BASEMENT MEMBRANE 117
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A 7 YEAR OLD BOY PRESENTED WITH GENERALIZED EDEMA. URINE EXAMINATION REVEALED MARKED ALBUMINURIA. SERUM BIOCHEMICAL EXAMINATIONS SHOWED HYPOALBUMINAEMIA WITH HYPERLIPIDEMIA. KIDNEY BIOPSY WAS UNDERTAKEN. ON LIGHT MICROSCOPIC EXAMINATION, THE KIDNEY APPEARED NORMAL. ELECTRON MICROSCOPIC EXAMINATION IS MOST LIKELY TO REVEAL - (AIIMS NOV 03) A) FUSION OF FOOT PROCESSES OF THE GLOMERULAR EPITHELIAL CELLS B) RAREFACTION OF GLOMERULAR BASEMENT MEMBRANE C) DEPOSITION OF ELECTRON DENSE MATERIAL IN THE BASEMENT MEMBRANE D) THIN BASEMENT MEMBRANE ANS. IS ‘A’ I.E., FUSION OF FOOT PROCESS OF THE GLOMERULAR EPITHELIAL CELLS [REF: HARRISON 18,H/E P. 2345, 121
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TRUE ABOUT LIGHT MICROSCOPY IN MINIMAL CHANGE DISEASE IS - (AIIMS NOV 01) A) LOSS OF FOOT PROCESS SEEN B) ANTI GBM ABS SEEN C) IGA DEPOSITS SEEN D) NO CHANGE SEEN ANS. IS ‘D’ I.E., NO CHANGE SEEN [REF: HARRISON 18,H/EP. 2345, 2346; 17H/E P. 1790; NELSON 17H/EP. 1754] 124
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ONCE AGAIN: IMPORTANT QUESTIONS ON MINIMAL CHANGE DISEASE MOST COMMON CAUSE OF NEPHROTIC SYNDROME IN CHILDREN.
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