Study ended prematurely ketamine as an adjunct

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Study ended prematurely.
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KETAMINE AS AN ADJUNCT TREATMENT FOR DEPRESSION 4 not have a previous history of psychosis, bipolar disorder, positive drug screen, receiving ketamine for depression, any contraindications for Ketamine, or under involuntary admission status. G. Kheirabadi, D. Kheirabadi, Vafaie, Mirlouhi, and Hajiannasab (2019) The purpose of this study is to compare the efficacy of Ketamine in treating depression when compared to Electroconvulsiv e therapy (ECT). n=32, Admitted to ECT center in Iran, 19-59 years old, no hx of psychosis, drug abuse < 3 mo, delirium following Ketamine, current pregnancy, breastfeeding, or serious physical conditions Experimental Block Randomized Pretest-Posttest Control Group Design Hamilton Depression Rating Scale (HDRS) - 7 to 29 items (depending on version) scored either on a 3-point or 5-point Likert- type scale Wechsler Memory Scale (WMS) - a neuropsychologica IV Ketamine may have same antidepressant effects as ECT without loss of memory, but does not last as long.
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KETAMINE AS AN ADJUNCT TREATMENT FOR DEPRESSION 5 l test designed to measure different memory functions in a person Nugent, Wills, Gilbert, and Zarate (2018) The purpose of this study is to replicate previous findings that Ketamine’s antidepressant effects are related to creating synaptic potential in the human cortex. n=56, 31 with MDD(58% female) and 25 healthy controls (58% female) averaging 35±10 years old. Experimental, pretest-posttest crossover design. Ketamine-IV MDD group-DV HC group-DV Montgomery- Åsberg Depression Scale (MADRS) - a ten-item diagnostic questionnaire which psychiatrists use to measure the severity of depressive episodes in patients with mood disorders CTF 275 channel MEG scanner with MRI imaging - system measures brain waves. MRI brain mapping Findings show increased synaptic response after ketamine infusion.
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KETAMINE AS AN ADJUNCT TREATMENT FOR DEPRESSION 6 allows for 3D images of the brain showing real-time changes in brain current. Ionescu, Bentley, Eikermann, Taylor, Akeju, Swee, Pavone, Petrie, Dording, Mischoulon, Alpert, Brown, Baer, Nock, Fava, and Cusin (2018) The purpose of this study is to study the efficacy and longevity of Ketamine’s antidepressant and antisuicidal properties when compared to placebo. Ages 18-65, primary dx: MDD, HDRS ≥ 20, Hx of ≥ 3 failed antidepressant treatment regimes, “distressing” levels of SI >3 mo, but not severe enough to need immediate hospitalization, able to maintain Experimental Pretest-Posttest Random Control Group Design Ketamine-IV Intervention group-DV HDRS - 28-item rating scale that assesses symptoms of depression experienced over the past week scored either on a 3-point or 5-point Likert-type scale Columbia-Suicide Severity Rating Scale (C-SSRS) SI score - captures the presence of Despite previous study results, this study showed that ketamine did NOT outperform placebo in the treatment of depression.
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  • Fall '16
  • Denise Cauble

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