It blocks potassium channels in distal motor terminal

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It blocks potassium channels in distal motor terminal thus prolonging depolarization and enhancing the release of Acetylcholine containing vesicles. 3, 4-DAP can be given alone or in combination with pyridostigmine. 418
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Guillian Barre Syndrome 419
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Which of the following statement is true regarding Landry Guillian Barre Syndrome - (PGI Dec 01) a) Facial nerve palsy occurs b) Proximal muscle weakness c) Areflexia d) Pyramidal signs e) Distal muscle weakness 420
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This acute condition is the most common cause of acute or subacute generalized paralysis . It affects children and adults of all ages and both sexes. . The paralysis usually follows a nonspecific viral infection by about 10 days. . The viral infection may be gastrointestinal or upper respiratory infection. • Campylobacter jejuni is the most frequent identifiable antescedent infection 421
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Symptoms:- The major clinical manifestations are motor manifestations i.e., weakness that evolves more or less symmetrically over a period of several days. • Weakness usually begins in the lower extremities and progressively involves the trunk, the upper limbs and finally the bulbar muscles a pattern known as landry ascending paralysis. . Proximal and distal muscles are involved relatively symmetrically but asymmetry is seen in 9% of patients • Deep tendon reflexes usually disappear. . The weakness progresses in about 5% of patient to total motor paralysis with respiratory failure within few days. 422
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Cranial nerve involvement can occur :- - The most common cranial nerve to be involved is facial nerve. Sometimes B/L facial nerve involvement can also occur. Other cranial nerves can be involved later on. Disturbance of autonomic function:- - (Sinus tachycardia and less often bradycardia, facial flushing, fluctuating hypertens ion and hypotension, loss of sweating or episodic profuse diaphoresis). 423
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Urinary retention occurs in about 15% of patients. - Bladder dysfunction usually occurs in severe cases. . Sensory involvement in case of Guillain Barre syndrome- - Cutaneous sensory deficits e.g loss of pain and temperature sensation are usually relatively mild but function subserved by large sensory fibres such as deep tendon reflexes and proprioception are maximmally affected. 424
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Which of the following statement is true regarding Landry Guillian Barre Syndrome - (PGI Dec 01) a) Facial nerve palsy occurs b) Proximal muscle weakness c) Areflexia d) Pyramidal signs e) Distal muscle weakness A, B, C, E. 425
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True about GBS is A/E- (NBE based AI 13 Pattern) a) Demyelination b) Prior viral infection c) Prior bacterial infection d) Predominant sensory involvement 426
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Guillain Barre syndrome is thought to result from an immune response to preceeding infection that cross reactss to peripheral nerve.
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  • Winter '16
  • jean grey

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