04 Cell Membranes and Signaling

Chemical connection between cells is mediated by

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Chemical Connection Between Cells Is Mediated by Chemical Messengers and Specific Receptors e.g. Specific Hormones e.g. Specific Hormone Receptors e.g. Endocrine Gland
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Complementary Shapes Determine Specificity of Binding
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Three-Dimensional Folding of Protein Determines the Shape of Binding Sites
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Three-Dimensional Structure of a Protein Determines Specificity of Binding
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Receptor-Ligand Binding Interactions are Saturable
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Shape and Charge Determine Binding Affinity of Ligand for a Binding Site
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Binding Affinity Describes Tightness of Receptor-Ligand Interactions Binding Affinity α 1/Kd Where Kd = Ligand Concentration at which 50% of Receptors are Bound KdY KdX KdY < KdX Y has Higher Affinity than X
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Competitive Inhibition Receptor + Ligand ↔ Receptor-Ligand → Response Inhibitor ↔Receptor-Inhibitor High [Ligand] can Overcome Competition by Inhibitor Ligand Concentration [Receptor-Ligand]
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1. -Bungarotoxin in snake venom is a competitive inhibitor of acetylcholine receptors at the neuromuscular junction and causes muscle paralysis. 2. Many drugs are competitive inhibitors of receptors or enzymes.
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Non-Competitive Inhibition Receptor + Ligand ↔ Receptor-Ligand → Response Inhibitor Irreversible Inactivation of Receptor High Ligand Concentration
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  • Spring '11
  • Chi-MingHai
  • Physiology, Membranes, intestinal epithelial cells, ligand concentration, Receptor Ion Channel, Major Signaling Mechanism

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