derivatives. Most of the drug is eliminated unchanged.Elimination - Amoxicillin and its metabolites are primarily excreted into the urine primarily via tubular secretion and glomerular filtration. Clearance of clavulanic acid has both a renal (25 to 50%) and a non-renal component. Clavulanic acid appears to be extensively
metabolized, although the exact mechanism is not fully established. A small percentage of amoxicillin; clavulanic acid is excreted in breast milk.ContraindicationsAsthma, carbapenem hypersensitivity, cephalosporin hypersensitivity, eczema, penicillin hypersensitivity, urticariaGeriatricDialysis, renal disease, renal failure, renal impairmentColitis, diarrhea, GI disease, inflammatory bowel disease, pseudomembranous colitis, ulcerative colitisChildren, infants, neonatesDosages must be modified because of incompletely developed renal function. Certain dosage forms are not for use in small children. The safety and effectiveness of amoxicillin/clavulanic acid extended-release tablets and regular tablets have not been established in pediatric patients weighing less than 40 kg. Children less than 40 kg of body weight should be dosed using oral suspension or chewable tablets. Neonates and infants < 3 months should be dosed using the 125 mg/5 mL oral suspension for dosing only.Labor, obstetric delivery, pregnancyBreast-feedingPhenylketonuriaAmoxicillin/clavulanic acid chewable tablets contain phenylalanine. Oral suspensions of amoxicillin/clavulanic acid. Should be used cautiously in patients with phenylketonuriaMononucleosisCholestasis, hepatic disease, jaundiceBlack box warnings– N/A
5. What health maintenance or preventive education is important for this client based on your choice medication/treatment? 2017). Control environment by using humidified air and increased fluid intake to relieve nasal discomfort and to liquefy secretions (Hall, 2017). Use warm, moist air (steam inhalation or warm compresses) to relieve headache and feeling of pressure in head/sinus areas (Hall, 2017). Refrain from any activity that might introduce fluid into the sinuses, such as swimming or diving (Hall, 2017). Advise to stop smoking. References Hall, M. (2017). Sinusitis. In T. Mahan Buttaro, J. Joanne Sandberg, J. Trybulski, & P. Polgar- Bailey (5 TH Ed.), Primary care. A collaborative practice (pp. 389-392). St. Louis, MI: Elsevier. PDR- Prescribers’s Digital Reference. (2019). Amoxicillin/clavulanate potassium – Drug
summary . Retrieved from - Tablets--Powder-for-Oral-Suspension--and-Tablets-amoxicillin-clavulanate-potassium- 2204.8453#10 Tewfik, T. L. (2018). Medical treatment for acute sinusitis guidelines. Retrieved from
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- Spring '19
- Sonya B.
- Beta-lactamase, Sinusitis, Upper respiratory tract infection, Clavulanic acid