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“Slow” Synaptic Transmission•G protein-coupled or metabotropic receptors•7 hydrophobic transmembrane-spanning regions with a long extracellular N-terminus and long intracellular C-terminus•GPCRs
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GPCR Super-family•3 major types of GPCRs–Gs, Gi/o and Gq– Gt/transducin in photoreceptors–Gg/gustducin in taste buds•Type of G protein present determines which intracellular signaling cascade(s) will be affected by ligand binding•Certain toxins interact with specific Gsubunits and inhibit particular intracellular signaling pathways