Slow synaptic transmission g protein coupled or

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“Slow” Synaptic Transmission G protein-coupled or metabotropic receptors •7 hydrophobic transmembrane- spanning regions with a long extracellular N-terminus and long intracellular C-terminus •GPCRs
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GPCR Super-family 3 major types of GPCRs Gs, Gi/o and Gq – Gt/transducin in photoreceptors Gg/gustducin in taste buds Type of G protein present determines which intracellular signaling cascade(s) will be affected by ligand binding Certain toxins interact with specific G subunits and inhibit particular intracellular signaling pathways
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