Consider your wbcs as a security force for your body

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Consider your WBCs as a security force for your body and any non-self antigens as pictures of a bad guy. The larger the force, the more likely one of the officers will run into a “bad guy” and so that the body will be able to apprehend it. But sometimes different branches of law enforcement need to work cooperatively in order to catch a criminal. (Think about the FBI putting a picture of a wanted criminal on INTERPOL … the International Criminal Police Organization). Any WBC that can grab and present an antigen to another, is called an _________ _____________ _______ (APC). APCs include B cells , macrophages and dendritic cells . Image: Antigen presentation , Sjef Third Line of Defense From the Virtual Microbiology Classroom on ScienceProfOnline.com
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Major Histocompatibility Complex (MHC) Collection of genes on chromosome 6 , which code for major histocompatibility glyco protein s. ______ proteins are in the plasma membrane of all your nucleated cells (non-professional APCs) ______ proteins are found only in the plasma membrane B cells and special antigen presenting cells (professional APCs, such as macrophages & dendritic cells.) MHC glycoproteins function to hold and position antigenic determinants for presentation to other cells. (Think of them as antigen holders.) Some lymphocytes only recognize antigenic determinants that are bound to MHC molecules . Image: MHC class I , and MHC class II ; atropos235; Chromosome & gene , Graham Colm From the Virtual Microbiology Classroom on ScienceProfOnline.com
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T Lymphocytes (T cells) Produced in red bone marrow and mature in thymus. Circulate in the lymph and blood and migrate to the lymph nodes (and other areas of the lymph system). Part of the cellular immune response (aka cell-mediated immune response) because these cells act directly against various antigens Endogenous invaders (intracellular pathogens inside the body’s cells) Abnormal body cells such as cancer cells Types _______ or ____ T cells ( T C ) ________ T cells ( T H ) Image: Antigen presentation , Sjef Third Line of Defense: Cell-mediated Immune Response From the Virtual Microbiology Classroom on ScienceProfOnline.com
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T Cell Receptors (TCRs) Molecules found on surface of T lymphocytes that recognize antigens bound to major histocompatibility complex (MHC) molecules. Interaction of the TCR with antigen and MHC molecules results in activation of the T lymphocyte. The T-cell releases cytokines. The cell reproduces and differentiate into T cells ( T C ) and T cells ( T H ) Image: T cell activation , NIH Third Line of Defense: Cell-mediated Immune Response From the Virtual Microbiology Classroom on ScienceProfOnline.com
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Cytotoxic T Cells (T C Cells) Also called Killer T cells. Involved in _______ ______ ________ _________. Directly kill cells of the body that are abnormal or infected with viruses and other intracellular pathogens.
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