Blood Gases Objectives

Is a weak acid bc it does not completely dissociate

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is a weak acid b/c it does not completely dissociate into H + and HCO 3 - . When an acid is added to the bicarbonate-carbonic acid system, the HCO 3 - will combine w/ the H + from the acid to form H 2 CO 3 . When a base is added, H 2 CO 3 will combine w. the OH - group to form H2O and HCO 3 - . It’s an important buffer for 3 reasons (1.) H 2 CO 3 dissociates into CO 2 and H2O, allowing CO 2 to be eliminated by the lungs and H + as water (2.) changes in CO2 modify the ventilation rate (3) HCO 3 - concentration can be altered by the kidneys. 3. Explain the clinical significance of the following blood gas parameters: pH, pCO2, pO2, HCO3-, O2 Saturation, COHb pH Normal: 7.35-7.45 pH < 7.35 – Acidosis pH > 7.45 - Alkalosis The lungs and kidneys play important roles in regulating blood pH. The interrelationship of the lungs and the kidneys is depicted in the Henderson-Hasselbalch equation. The numerator (HCO 3 - ) denotes kidney function, whereas the denominator (pCO2, which
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Blood Gases/Acid-Base Balance – Objectives represents H 2 CO 3 denotes lung function. The lungs regulate pH thru retention or elimination of CO2 by changing the rate and volume of ventilation. The kidneys regulate pH by excreting acid, primarily in the ammonium ion, and by reclaiming HCO 3 - from the glomerular filtrate. pCO2 = (H 2 CO 3 ) In health, when the kidneys and lungs are functioning properly, a 20:1 ratio of HCO 3 - to H 2 CO 3 will be maintained (resulting in a pH of 7.40).
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  • Fall '12
  • professoridon'tknow
  • pH, Bicarbonate, alkalosis, Blood Gases/Acid-Base Balance

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