PHRM 514 STD's Fall 2012 (1)

Sexually transmitted diseases in dipiro jt talbert rl

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Knodel, LC.  Sexually transmitted diseases.  In:  DiPiro JT, Talbert RL, Yee GC, et al., editors.  Pharmacotherapy a  pathophysiologic approach.  8th ed.  New York:  McGraw Hill Medical; 2011:2011-2028.
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Gonorrhea:  Complications Males Females Complications n Rare Epididymitis,  prostatis, inguinal  lymphadenopathy,  urethral stricture n Disseminated gonorrhea n Pelvic inflammatory  disease (occurs in 15% of  cases) May lead to ectopic  pregnancy, infertility n Disseminated  gonorrhea* *3x more likely in females than males Knodel, LC.  Sexually transmitted diseases.  In:  DiPiro JT, Talbert RL, Yee GC, et al., editors.  Pharmacotherapy a  pathophysiologic approach.  8th ed.  New York:  McGraw Hill Medical; 2011:2011-2028.
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Gonococcal Infection in Pregnancy n Neonates may acquire during passage  through the birth canal n Neonatal conjunctivitis (ophthalmia  neonatorum) § May result in blindness if not treated promptly Knodel, LC.  Sexually transmitted diseases.  In:  DiPiro JT, Talbert RL, Yee GC, et al., editors.  Pharmacotherapy a  pathophysiologic approach.  8th ed.  New York:  McGraw Hill Medical; 2011:2011-2028.
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Gonorrhea:  Diagnosis n Gram stain § Used for males with symptomatic urethritis (discharge) n Specific testing for  N. gonorrhoeae § Cultures and nucleic acid hybridization § Use endocervival or urethral (men only) specimens § Nucleic acid amplications tests (NAAT’s) § Use endocervical, vaginal, urethral (men only), or urine  specimens § May use self-collected specimens § Superior sensitivity to culture § No antimicrobial susceptibility testing Knodel, LC.  Sexually transmitted diseases.  In:  DiPiro JT, Talbert RL, Yee GC, et al., editors.  Pharmacotherapy a  pathophysiologic approach.  8th ed.  New York:  McGraw Hill Medical; 2011:2011-2028. Centers for Disease Control and Prevention.  Sexually Transmitted Diseases Treatment Guidelines.  MMWR  2010;59(RR-12):1-116.
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Chlamydia
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Chlamydia 2010 Statistics n 1,307,893 reported cases n 426 cases/100,000 people § Women 610.6 cases/100,000 § Men 233.7 cases/100,000 n Increased 5.1% from 2009 Centers for Disease Control and Prevention.  Sexually Transmitted Disease Surveillance 2010.  Atlanta: U.S. Department of Health and Human Services; 2011.
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Chlamydia:  Microbiology n Caused by  Chlamydia trachomatis n Intracellular gram negative bacteria § Require material from host cells for replication § Maintain cellular identity throughout development Knodel, LC.  Sexually transmitted diseases.  In:  DiPiro JT, Talbert RL, Yee GC, et al., editors.  Pharmacotherapy a  pathophysiologic approach.  8th ed.  New York:  McGraw Hill Medical; 2011:2011-2028.
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Chlamydia:  Pathophysiology Gaydos CA, Quinn TC. Chapter 176. Chlamydial Infections. In: Longo DL, Fauci AS, Kasper DL, Hauser SL, Jameson 
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