PHRM 514 STD's Fall 2012 (1)

Urethral infection – dysuria urinary frequency

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Unformatted text preview: Urethral infection – dysuria, urinary frequency Anorectal and pharyngeal infection – same as for males Signs Purulent urethral or rectal discharge (scant to profuse) Anorectal – pruritus, mucopurulent discharge, Abnormal vaginal discharge, uterine bleeding, purulent urethral or rectal discharge (scant Knodel, LC. Sexually transmitted diseases. In: DiPiro JT, Talbert RL, Yee GC, et al., editors. Pharmacotherapy a pathophysiologic approach. 8th ed. New York: McGraw Hill Medical; 2011:2011-2028. Gonorrhea: Complications Males Females Complications n Rare • Epididymitis, prostatis, inguinal lymphadenopathy, urethral stricture n Disseminated gonorrhea n Pelvic inflammatory disease (occurs in 15% of cases) • May lead to ectopic pregnancy, infertility n Disseminated gonorrhea* *3x more likely in females than males Knodel, LC. Sexually transmitted diseases. In: DiPiro JT, Talbert RL, Yee GC, et al., editors. Pharmacotherapy a pathophysiologic approach. 8th ed. New York: McGraw Hill Medical; 2011:2011-2028. Gonococcal Infection in Pregnancy n Neonates may acquire during passage through the birth canal n Neonatal conjunctivitis (ophthalmia neonatorum) § May result in blindness if not treated promptly Knodel, LC. Sexually transmitted diseases. In: DiPiro JT, Talbert RL, Yee GC, et al., editors. Pharmacotherapy a pathophysiologic approach. 8th ed. New York: McGraw Hill Medical; 2011:2011-2028. Gonorrhea: Diagnosis n Gram stain § Used for males with symptomatic urethritis (discharge) n Specific testing for N. gonorrhoeae § Cultures and nucleic acid hybridization § Use endocervival or urethral (men only) specimens § Nucleic acid amplications tests (NAAT’s) § Use endocervical, vaginal, urethral (men only), or urine specimens § May use self-collected specimens § Superior sensitivity to culture § No antimicrobial susceptibility testing Knodel, LC. Sexually transmitted diseases. In: DiPiro JT, Talbert RL, Yee GC, et al., editors. Pharmacotherapy a pathophysiologic approach. 8th ed. New York: McGraw Hill Medical; 2011:2011-2028. Centers for Disease Control and Prevention. Sexually Transmitted Diseases Treatment Guidelines. MMWR 2010;59(RR-12):1-116. Chlamydia Chlamydia 2010 Statistics n 1,307,893 reported cases n 426 cases/100,000 people § Women 610.6 cases/100,000 § Men 233.7 cases/100,000 n Increased 5.1% from 2009 Centers for Disease Control and Prevention. Sexually Transmitted Disease Surveillance 2010. Atlanta: U.S....
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Urethral infection – dysuria urinary frequency Anorectal...

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