The M\u00fcllerian female systemneedsno hormonal developit

The müllerian female systemneedsno hormonal developit

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The Müllerian (female) systemneedsno hormonal stimulusfromthegonadsto develop;it justnormally doesso. Resultsin Feminization Wolffian (male) systemdo notdevelop unlessthey arestimulated to do so by a hormone! Masculinization Defeminization. Development of the Sex Organs Internal Sex Organs Wolffian system develops via stimulation by two hormones secreted by the testes. Development of the Sex Organs Internal Sex Organs Fro m P h ysio l Rev Ja n u a ry 20 07 vo l.8 7 no .1 1-2 8 1. anti-Müllerian hormone peptide (AMH) It preventsthe Müllerian (female) system from developing. Defeminization Androgens : stimulatesthe development of the Wolffian system. Masculinization AMH 2 androgens: Testosterone = secreted by the testes Dihydrotestosterone (DHT) Testerone à 5 a reductase à DHT
9/9/16 8 Wolffian system—containsandrogenreceptors that arecoupledtocellular mechanisms that promotegrowthanddivision. When androgensbind withthesereceptors,the epididymis, vas deferens,andseminal vesicles develop andgrow. Mülleriansystemcontainreceptorsforanti- Müllerianhormone that prevent growthand division. Presenceof anti-Müllerianhormone prevents thedevelopment of the femaleinternalsex organs. Development of the Sex Organs Internal Sex Organs 1 3 1 3 6 1/ doi: 10.1530/REP-09-0415 Some people areinsensitiveto androgens= androgen insensitivitysyndrome. Caused by genetic mutation à nofunctioning androgenreceptors. (genefor the androgenreceptor islocatedontheX chromosome) Theprimitive gonadsof a genetic malefetuswithandrogeninsensitivitysyndrome becometestesandsecretebothanti-Müllerianhormoneandandrogens. Thelack of androgenreceptorspreventstheandrogensfromhaving a masculinizing effect; thus,theepididymis, vas deferens,seminalvesicles, and prostatedonot develop. Developmentof the Sex Organs AndrogenInsensitivity (AIS)
9/9/16 9 In AIS, anti-Müllerian hormone (AMH) still present = defeminizing effect, preventing the female internal sex organs from developing. The uterus, fimbriae, and Fallopian tubes do not develop either, and the vagina is shallow. The external genitalia are female, and at puberty the person develops a woman’s body. Without a uterus and ovaries, the person cannot have children Wo ma n with AIS Fig u re fro m h ttp ://in tersexu a l.wo rd press.co m/ Developmentof the Sex Organs Androgen Insensitivity (AIS)
9/9/16 10 A genetic condition caused by either a lack of anti-Müllerian hormone or its receptor. When this syndrome occurs in genetic males, androgens have their masculinizing effect, but defeminization does not occur. Thus, the person is born with both sets of internal sex organs, male and female Developmentof the Sex Organs PersistentMullerian Duct Syndrome From Chaabane et al. 2010 In Urology Volume 76, Issue 1, The presence of the additional female sex organs usually interferes with functioning of the male sex organs Molecular probe test for SRY was intendedto ensure that potential competitors for the
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