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Note Jan 28, 2013 lecture 1

Connect different parts of e course to get an

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Connect different parts of e course to get an integrated view of cell biology and function Goals this week:- METHODS What is it? Proteins, lipids, purified proteins? Sketch of how experiments work What is being investigated What do the results mean? What are the limits of these experiments? If you look at a good scientific paper there are usually several different techniques used Where to start? What cells to use? Yeast, fruit fly, mouse, human (increasing in size) Yeast is genetically identical, easy to manipulate genome, con-only one type of yeast cell (no yeast liver cell) Fruit flies are sequenced, few ethical issues, can't store long term need to maintain stocks Mouses are expensive, inbred lines that are well understood, can me deletions in the genome relatively easily, good for whole organism systems- cant store mice, handling properly is labor intensive Humans have large cells, genetics are complicated, expensive, can't grow in lab-no inbred lines Can grow isolated cells in the lab Need cells from a multicellular organism 1 cell isn't enough - need controls If we have a mouse we can treat it in some way, dissect it, see how different cells behave (liver, brain, skin)( how does the treatment affect different tissues?)
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