Lecture6genetargetingHemophiliahumanchromosomes

Hemophilia a occurs in about 1 in 500010000 male

Info icon This preview shows pages 17–22. Sign up to view the full content.

View Full Document Right Arrow Icon
Hemophilia A occurs in about 1 in 5,000–10,000 male births, while Hemophilia B occurs at about 1 in 20,000-34,000. Hemophilias A and B, X-linked recessive disorders
Image of page 17

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Source and more info: hHp://www.ncbi.nlm.nih.gov/ books/NBK22589/ Hemophilia A Hemophilia B Blue: inactive clotting factor Orange: activated clotting factor Green: stimulatory clotting factor (not an enzyme) The clotting cascade
Image of page 18
Thrombin cleaves fibrinogen, the resulting fibrin units form a mesh = clot hHp://www.ncbi.nlm.nih.gov/books/NBK22589/
Image of page 19

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Clicker question: Which of the following treatments are likely to help patients with Hemophilia A? A. Intravenous injections with Factor VIII B. Intravenous injections of Factor IX C. Blood transfusions with Thrombin D. Intravenous injection with activated Factor X E. All of the above
Image of page 20
Management of Hemophilia Standard care: replacement of the deficient factor with recombinant Factor VIII (Hemophilia A) or IX (Hemophilia B), produced from cultured hamster cells Factor replacement therapy has increased life expectancy from an average of 11 years before 1960s to about 65 years today. Commercially produced factor concentrates such as "Advate", a recombinant Factor VIII produced by Baxter International , come as a white powder in a vial which must be mixed with sterile water prior to intravenous injection. Wikipedia
Image of page 21

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Summary
Image of page 22
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern