Group polymerase envelope antigen p17 p24 reverse

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group polymerase envelope antigen p17, p24 reverse gp120, gp41 integrase protease transcriptase Coat proteins Enzymes Surface proteins Genes Proteins
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29 HIV Integrase HIV Integrase HIV Provirus HIV DNA + Host cell Chromosome
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30 Function of HIV Protease HIV Protease gp41 + gp120 gp160 gp120 gp41 Spike:
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31 HIV Genes
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32 HIV Genome LTR —long terminal repeat = segments of DNA at ends of provirus; controls proviral DNA transcription tat gene: (transactivator) when tat is active, HIV replicates quickly; cell undergoes lysis rev gene: (r egulator of e xpression of v iral protein) rev can slow down or speed up viral replication
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33 Mutations occur during replication of HIV Reverse transcriptase = extremely error prone Estimated every round of replication = 1 mutation HIV has 2 RNA molecules = doubles mutation rate Mutations possible when RNA is reverse transcribed to DNA What are the consequences of these mutations???
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35 Mutations gp120 Mutation Time gp41 Spike: a d c b a-d = antigenic determinants gp120 gp41 w z y x w-z = new antigenic determinants
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36 Time Course of HIV Antibody Response weeks
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37 AIDS A generalized graph of the relationship between HIV copies (viral load) and CD4 counts over the average course of untreated HIV infection
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38 Escape of HIV from T cells • Budding • Lysis • Syncytia formation • Apoptosis • These mechanisms also contribute to death of T cells due to HIV infection
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