Bind specific histone modifications and direct downstream functions Have

Bind specific histone modifications and direct

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Bind specific histone modifications and direct downstream functions -Have protein domains that recognize specific modifications Example: Bromodomains Acetyl Chromodomains Methyl
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20 12.7 Epigenetics: There’s more to inheritance than DNA Different readers may specify different outputs for the same PTM Methyl lysine binding domains PHD fingers PWWP domains Chromo domains Tudor domains Ankyrin repeats WD repeats MBT domains Shi X, et al. Nature, 2006 Vermeulen M, et al. Cell, 2007 ING2 PHD TAF3 PHD Gene Repression Gene Activation K4 H3 K4 H3 me3 me3
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21 12.4 Heterochromatin Inactivated X-chromosome or Barr body (arrows) H4 Ac Antibody Heterochromatin is commonly characterized by DNA Methylation, Histone Methylation and Hypoacetylation
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22 12.4 Heterochromatin Model: Formation of Hetero- chromatin
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23 Epigenetics overview
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24 12.5 The structure of a mitotic chromosome Scanning electron micrograph of a mitotic chromosome with the centromere marked by a distinct indentation
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25 12.5 The structure of a mitotic chromosome Human mitotic chromosomes labelled with different specific fluorescent dyes In-situ hybridization with a DNA probe t o locate telomeres on human chromosomes FISH: Fluorescence in situ hybridization
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26 12.8 The nucleus as an organized organelle
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27 12.8 The nucleus as an organized organelle 3D Map of all of the chromosomes present in a human fibroblast nucleus Localizing specific chromosomes within an interphase nucleus
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28 12.8 The nucleus as an organized organelle Breast cancer cells treated with estrogen co-activate genes on Chr2 and Chr21 Model of how different DNA regions could be organized for gene expression
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29 12.9 An overview of gene regulation in eukaryotes Overview of levels of control of gene expression
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30 12.11 The role of transcription factors in regulating gene expression Transcription overview
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31 Transcription overview 12.11 The role of transcription factors in regulating gene expression
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