vs. 0.61 for neck circumference in males, and 0.66 vs. 0.66 in females). Conclusion: Neck circumference is positively and independently associated with hyperuricemia in both genders and is also associated with serum uric acid levels in the non-hyperuricemia population. Keywords: neck circumference, waist circumference, serum uric acid, hyperuricemia, association INTRODUCTION Epidemiology studies from mainland China spanning 2000–2014 have shown that the prevalence of hyperuricemia is 13.7% in urban Chinese and 12.3% in rural Chinese individuals ( Liu et al., 2015 ). Hyperuricemia causes gouty arthritis ( Zamudio-Cuevas et al., 2015 ), kidney stones ( Mirheydar et al., 2014 ) and chronic renal failure ( Tsai et al., 2017 ), which significantly impact quality of
Jiang et al. Neck Circumference and Hyperuricemia life ( Scire et al., 2013 ). Hyperuricemia has also been considered to be a risk factor for metabolic syndrome ( Cibicková et al., 2017; Rubio-Guerra et al., 2017 ), diabetes mellitus ( Wang et al., 2013 ), hypertension ( Lyngdoh et al., 2012 ), stroke ( Wu et al., 2017 ), chronic kidney disease ( Ceriello et al., 2017 ) and cardiovascular disease ( Qin et al., 2014; Amin et al., 2017; Moulin et al., 2017 ). Hyperuricemia is therefore a serious public health problem that should be detected early and treated. However, the predictors of hyperuricemia are not well-known. Waist circumference, an indicator of abdominal obesity, has been reported to be associated with hyperuricemia in Chinese ( Wang et al., 2013; Zhang et al., 2016 ), African Americans ( McAdams-DeMarco et al., 2013 ) and Japanese individuals ( Suma et al., 2014 ). The association of waist circumference and hyperuricemia was shown in a recent large study from China ( Chen et al., 2017 ). The underlying mechanism linking waist circumference to hyperuricemia may be attributed to the excess free fatty acids released from the visceral fat, causing cellular fat accumulation and consequent lipotoxicity-mediated injury to multiple organs, which in turn would contribute to the metabolic disorder inflicted by uric acid on the kidney and liver ( Weinberg, 2006; Yamada et al., 2016 ). Circulating free fatty acids have been postulated to emanate from the subcutaneous fat of the upper body ( Martin and Jensen, 1991 ). Here, neck circumference was considered a predictive anthropometric measure of upper body fat distribution ( Wang et al., 2015; Luo et al., 2017 ). Taken together, this finding serves as the rationale for our hypothesis that large neck circumference is associated with hyperuricemia. To the best of our knowledge, there has not been a study that has focused on assessing the association between neck circumference and hyperuricemia. A major aim of this study is therefore to examine whether neck circumference is associated with hyperuricemia and serum uric acid levels in non-hyperuricemia subjects. This study is also aimed at comparing the strength of association of neck circumference and waist circumference with hyperuricemia and their ability to detect hyperuricemia.
- Spring '16
- Uric acid, Hyperuricemia