Eg pharmacological or physiological effects routes of

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- e.g. pharmacological or physiological effects
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Routes of infection Ingestion - by mouth Inhalation - breathed in Percutaneous - across damaged skin or mucous membranes Instillation in eye Direct or by transfer on hands etc.
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Basis for control measures - Block all routes of infection Do not put anything in mouth Do not create aerosols Cover damaged skin and minimise risk of puncture wounds Do not produce splashes and droplets Do not transfer to any route with hands or other contaminated objects
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Biosafety Cabinets The terms biological safety cabinet and biosafety cabinet have been widely used to describe a variety of containment devices equipped with HEPA filter(s), HEPA: High Efficiency Particulate Air The “classical” definition of HEPA filter is 99.97% at 0.3 microns , but nowadays all BSC in US use 99.99% at 0.3 µm HEPA Capability : Removes a broad range of airborne contaminants: Fine dust • Smoke • Bacteria (typical size: 500 to 0.3 micron) • Soot • Pollen • Radioactive particles • Impurity ion -> can affect Integrated Circuit speed
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International Standards on Biosafety Cabinet Mainly issued by two Organisations : - International Standard Organisation (ISO), based in Geneva (Switzerland). - Comitee Europeen de Normalisation (CEN) based in Brussels (Belgium) These standards replace all other local standards on the same subject. The aim of the standards is to construct a mechanism to provide manufacturer and user of a common site to specify technical specifications and features. Both construction and testing of the cabinet are covered
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Difference between Hood and Safety Cabinet
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Fume hood It is s a ventilation device that is designed to limit exposure to hazardous fumes vapors or dust. A fume hood is typically a large piece of equipment enclosing five sides of a work area, the bottom of which is most commonly located at a standing work height. Two main types exist : ducted and recalculating. The principle is the same for both types: air is drawn in from the front (open) side of the cabinet, and either expelled outside the building or made safe through filtration and fed back into the room.
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Laminar Flow Only for Product Protection No Personnel or Environment Protection A. front opening B. supply grille C. supply HEPA filter D. supply plenum E. blower F. Grille
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Classification of Bio Safety Cabinet
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Classification of Biosafety Cabinet Biosafety Cabinet Class I: Personnel and Environment protection. Product is not protected. Class II: Personnel, Product and Environment are protected. Class III: Maximum protection to Personnel, Product and Environment.
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Class I Biosafety Cabinets A. Front opening B. Sash C. Exhaust HEPA Filter D. Exhaust plenum This is a negative-pressure, ventilated cabinet usually operated with an open front.
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