co-transport Na+ choline Chapter 6 Chapter 6
QUESTION #29 ___________________ are involved in movement, mood, attention, and visceral function. Catecholaminergic Neurons Chapter 6 Chapter 6
QUESTION #30 __________ is a precursor for three amine neurotransmitters that contain catechol group. The three amine neurotransmitters would be: ___________, ___________, and _____________________________. These are all known as __________ neurotransmitters. Tyrosine dopamine norepinephrine epinephrine (adrenaline, also a hormone) excitatory Chapter 6 Chapter 6
QUESTION #31 Identify the amine neurotransmitters. 1 2 3 Chapter 6 Chapter 6
QUESTION #32 Dopamine is implicated in all of the following diseases EXCEPT: A. Tourette’s syndrome B. Parkinson’s disease (PD) C. Schizophrenia D. Social phobia E. Attention-deficit hyperactivity disorder (ADHD) F. Drug and alcohol addiction G. None of the above Chapter 6 Chapter 6
QUESTION #33 _______________________are an amine neurotransmitter (_________) derived from ___________. Regulates mood, emotional behavior, sleep. excitatory tryptophan Serotonergic (5-HT) neurons Chapter 6 Chapter 6
QUESTION #34 GABA-glycine, dopamine-glutamate, dopamine-GABA, ACh- glutamate are all examples of ____________. Co-releases Chapter 6 Chapter 6
QUESTION #35 Selective serotonin reuptake inhibitors (SSRIs are also known as ____________. antidepressants Chapter 6 Chapter 6
QUESTION #36 Differences among amino acidergic neurons are _________, not ________, (all cells have aa). quantitative qualitative Chapter 6 Chapter 6
QUESTION #37 Hints : 1. Key enzyme in GABA synthesis. 2. Good marker for GABAergic neurons. 3. GABAergic neurons are major source of synaptic inhibition in the CNS. Glutamic acid decarboxylase (GAD) Glutamic acid decarboxylase (GAD) Chapter 6 Chapter 6
QUESTION #38 Amphetamine pleasurable feeling and addiction are believed to be mediated through increased _________ neurotransmission . dopamine Chapter 6 Chapter 6
QUESTION #39 Identify if the following are excitatory or inhibitory . Chapter 6 Chapter 6
QUESTION #40 _______________ is when AChRs stay close and synaptic transmission will fail. This is what happens with nerve gases in the diaphragm muscle, causing respiratory failure. Desensitization Chapter 6 Chapter 6
QUESTION #41 ________ is the primary neurotransmitter of the reward pathway . Dopamine Chapter 6 Chapter 6
QUESTION #42 True or false , dopamine has functions in non-CNS organs. Chapter 6 Chapter 6
QUESTION #43 Neurotransmitter are suppose to act very fast, to have a transient action. Therefore there are enzymes to degrade them quickly or transporters to take them back. Chapter 6 Chapter 6
QUESTION #44 ACh : degraded by Acetylcholinesterase (AChE), one of the fastest catalytic enzyme. Catecholamines : can be inactivated by methylation or by oxidation (deamination). In addition, they can be pumped back into the presynaptic terminal with specific transporters (reuptake) . Chapter 6 Chapter 6
QUESTION #45 COMT (catechol-O- methyltransferase Catecholamine methylation is mediated by these enzymes.
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- Spring '19