Two electrons from fadh 2 are transferred to coq

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Two electrons from FADH 2 are transferred to CoQ. Electrons are passed to cyctochromes. Does not pump any protons. Complex III : CoQH 2 -cytochrome c oxidoreductase An integral membrane protein complex. Transfers electrons from CoQ to cytochrome c one electron at a time. Four protons are pumped for each pair of electrons transferred. Complex IV : Cytochrome c oxidase An integral membrane protein complex. Contains cyt a and cyt a 3 Accepts one electron at a time from cytochrome c. Donates a total of four electrons/O 2 . Site of oxygen reduction to water. Produces 2 water molecules/O 2 molecule. Pumps an additional two protons across the membrane. ATP Synthesis ATP synthesis occurs in the mitochondrial matrix. The endergonic formation of ATP from ADP + P i is driven by two factors related to the electron transport described above. 1. The proton gradient. The transport of electrons caused protons to be pumped out of the matrix space. The resulting difference in pH can be coupled to ATP synthesis. 2. The membrane potential. The transport of H + out leaves the matrix at a negative electrical potential relative to the cytosol. The resulting difference in membrane potential can be coupled to ATP synthesis.
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3 The free energy available for ATP synthesis can be calculated by combining the terms for the above contributions: G = 2.3RT pH + Z F ∆Ψ , where: pH = pH out - pH in ; Z = the proton charge; F = the Faraday constant (96,494 J/volt-mol); ∆Ψ = the membrane potential (volts).
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