Typical solvents used in extraction ether ethyl

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Typical solvents used in extraction Ether, Ethyl Acetate, Dichloromethane Are these solvents top layer or bottom? Techniques Mixing Cap, invert, swirl Venting Allow pressure to be released Separating Bottom layer goes out bottom Top out top
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Question: Let’s say you dissolve 1 gram of freebased cocaine (K = 4.0) in 15 mL water. How many grams will be in your aqueous layer after an extraction with 15 mL ether?
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What if you did the extraction 3 times?
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What if you just used 45 mL of ether in one big extraction? Why isn’t this better?
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No solvent we use is really 100% immiscible with water Must have techniques to remove traces left over from extraction First: Brine wash Saturated NaCl in water Organic fractions are “washed” with brine Second: Drying additive Anhydrous inorganic salt that likes to form hydrates Molecular seives Zeolite
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Anhydrous Inorganic Salts Na 2 SO 4 + H 2 O Na 2 SO 4 x H 2 O
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