Chromocentres x chromosome inactivation figure after

Info icon This preview shows pages 21–28. Sign up to view the full content.

View Full Document Right Arrow Icon
Chromocentres
Image of page 21

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
X chromosome inactivation Figure after M. Barr (1963)
Image of page 22
Brian P Chadwick, Huntington F Willard Multiple spatially distinct types of facultative heterochromatin on the human inactive X chromosome. Proc. Natl. Acad. Sci. U.S.A.: 2004, 101(50);17450-5 PMID:15574503 X chromosome inactivation
Image of page 23

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Distribution of histone marks throughout the genome determined and mapped by C hromatin I mmunoP recipitaion (ChIP )
Image of page 24
Park (2009) Nature Rev. Genetics 10, 669
Image of page 25

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
ChIP profiles ChIP-chip ChIP-seq ChIP-seq Park (2009) Nature Rev. Genetics 10, 669
Image of page 26
Figure 2 | chiP profiles. a | Examples of the profiles generated by chromatin immunoprecipitation followed by sequencing (ChIP seq) or by microarray (ChIP chip). Shown is a section of the binding profiles of the chromodomain protein Chromator, as measured by ChIP chip (unlogged intensity ratio; blue) and ChIP seq (tag density; red) in the Drosophila melanogaster S2 cell line. The tag density profile obtained by ChIP seq reveals specific positions of Chromator binding with higher spatial resolution and sensitivity. The ChIP seq input DNA (control experiment) tag density is shown in grey for comparison. b | Examples of different types of ChIP seq tag density profiles in human T cells. Profiles for different types of proteins and histone marks can have different types of features, such as: sharp binding sites, as shown for the insulator binding protein CTCF (CCCTC-binding factor; red); a mixture of shapes, as shown for RNA polymerase II
Image of page 27

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Image of page 28
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern