decreased and he complained of increasing shortness of breath. At this point the doctors decided the patient needed to be sent to the intensive care unit for start of inotropic drip. Pharmacokinetics refer to the way drugs move through the body (Arcangelo & Peterson, 2013). Pharmacodynamics refers how the drug affects the body (Arcangelo & Peterson, 2013). Diuretics cause an increase in water and sodium excretion by the kidney (Arcangelo & Peterson, 2013). Mr. J initial response to the diuretics was the response expected of the diuretic, increased urinary output, weight loss, and decrease in shortness of breath. He then begin with diuretic resistance hence the increase in the Lasix dosage (Peacock et. al, 2009). Mr. J’s blood pressure decreased and kidney function decreased as well as potassium levels. Chronic treatment with diuretics causes potassium depletion. Diuretics may increase the risk of renal dysfunction, perhaps related to an acute reduction in blood pressure resulting from intravascular volume depletion (Peacock et. al, pg. 18, 2009). Due to the negative effects of the increase of Lasix (furosemide), Mr. J had to be transferred to continue the CHF treatment as well as monitor and intervene with the patient’s renal dysfunction, low blood pressure and low potassium levels.
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