science, CINAHL EBSCO, CochraneLibrary, PubMed Publisher and Google Scholar1537 articles were identified, 18 were read and 9 studies were included. Methodologicalstudy quality was estimated accdg. tothe 27-item scoring system of Downs and Black. All 9 studieswere designed as prospective quasi-experimental before-after andone was a multi-center studyThe pooled IRR showed that theantiseptic barrier cap was effective in reducing CLABSIsPublication bias was present, low number of studies included 9 out of 1537. 3 of 9CLABSI definition is not clear, only quasi-experimental studies were included, no RCTs8 studies were conducted inthe U.S and 1 in UK. Conducted in multi-departmentWright M.O, Tropp J, Schora D. M., Dillon-Grant M, Peterson K., Boehm S., Robicsek A., Peterson L. R. (January 2013) Continuous passive disinfection of catheter hubs prevents contamination and bloodstream infection. American Journal of Infection Control. 41(1) 33-38. doi-org.ezproxy.snhu.edu/10.1016/j.ajic.2012.05.0303 phased multi-facility quasi-experimental prospective design.Baseline-intervention-baselinePhase 1 – baseline standardscrub was used. Phase 2 – intervention when the cap wasused on all central lines. Phase 3 - back tobaseline.Northshore healthsystem. 931 beds, all inpatient adults. 799 enrollees.Patients with central line having 5+ consecutive line days had 1.5 mL of blood withdrawn and cultured on days 5, 6 or 7 and twice weekly thereafter.Disinfectant caps reduce the line contamination, organism density and CLABSI.The lack of compliance in using the disinfectant cap would biasthe findings.4 hospital University ofChicago-affilaited health system. The study had similar results.
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