Tt of choice is valproate 21 inclusion bodies seen in

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T/T of choice is valproate 21
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Inclusion bodies seen in progressive myoclonic epilepsy - (NBE/DNB Pattern) a) Buschino bodies b) Lewy bodies c) Hirano bodies d) Lafora bodies 22
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Inclusion bodies seen in progressive myoclonic epilepsy - (NBE/DNB Pattern) a) Buschino bodies b) Lewy bodies c) Hirano bodies d) Lafora bodies Ans. is ‘d’ i.e., Lafora bodies 24
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Lafora Bodies (a myloid bodies, myoclonus bodies, polyglucosan bodies) :- Rounded periodic acid schif-positive , argyophillic intracytoplasmic inclusion bodies with a dense central basophilic core and a rim that takes up less stain found in the larger neurons of the thalamus, dentate nuclei and substantia nigra in progressive myoclonic epilepsy (lafora body disease) and less abundanthy in normal aged brain. 25
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Which of the following drugs is effective as monotherapy as a replacement for sodium valproate in a female of childbearing age group for treatment of juvenile myoclonic epilepsy - (AIIMS May 13) a) Levetiracetam b)Lacosamide c) Phenytoin d) Carbamazepine 26
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Treatment of Juvenile myoclonic epilepsy: Valproate is the first line treatment of choice for most patients. However valproate should be avoided in women of child bearing age , particularly those who are considering becoming pregnant because of its teratogenic risks. For patients in whom valproate is contraindicated or not tolerated treatment is done with the following drugs: - Levetiracetam - Lamotrigine - Topiramate 27
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Which of the following drugs is effective as monotherapy as a replacement for sodium valproate in a female of childbearing age group for treatment of juvenile myoclonic epilepsy - (AIIMS May 13) a) Levetiracetam b)Lacosamide c) Phenytoin d) Carbamazepine Ans. is 'a' i.e. Levetiracetam 29
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Status epilepticus All of the following drugs are used for managing status epilepticus except – (AIIMS 06) a) Phenytoin b) Diazepam c) Thiopentone sodium d) Carbamazepine 30
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STATUS EPILEPTICUS Status epilepticus refers to continuous seizures or repetitive, discrete seizures with impaired consciousness in the interictal period. Status epilepticus has numerous subtypes , including generalized convulsive status epilepticus (GCSE) (e.g. persistent, generalized electrographic seizures, coma, and tonic-clonic movements), and non convulsive status epilepticus (e.g., persistent absence seizures or focal seizures, confusion or partially impaired consciousness, and minimal motor abnormalities). 31
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The duration of seizure activity sufficient to meet the definition of status epilepticus has traditionally been specified as 15–30 minutes. 32
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Status epilepticus All of the following drugs are used for managing status epilepticus except – (AIIMS 06) a) Phenytoin b) Diazepam c) Thiopentone sodium d) Carbamazepine D 35
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Which of the following is the drug of choice for absence seizure - (NBE/DNB Pattern) a) Phenytoin b) Valproate c) Carbamazepine d) Phenobarbitone Ans. is ‘b’ i.e., Valproate The first line drues for absence seizures includes Valproic acid and Ethosuxamide.
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  • Winter '16
  • jean grey

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