Factor XII Hageman factor activates kinin The ultimate function of this system

Factor xii hageman factor activates kinin the

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The coagulation cascade has a role in activating the kinin system. Factor XII (Hageman factor) activates kinin. The ultimate function of this system is to form a fibrin mesh to stop bleeding and to trap microorganisms. Released chemotactic factors attract neutrophils, eosinophils & monocytes all of which begin to perform phagocytosis. Neutrophils will show up at the site of injury in 6-8 hours and monocytes will show up in 1-7days. They each are responsible for phagocytosis. They will eventually die and rupture releasing their intracellular contents. This also triggers the release of the acute phase reactants. Mast cell degranulation is the major step of the inflammatory cascade and has an effect on every other aspect of the inflammatory cascade. Mast cell degranulation leads to the additional activation of the acute phase reactants which are the coagulation proteins, kinin and complement, but this is not depicted on the diagram. I simply want you to know that mast cell degranulation also triggers the activation of the acute phase reactants. Mast cell degranulation results in the release of four main items: histamine, cytokines, leukotrienes, & prostaglandins. Histamine is responsible
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  • Fall '15
  • david,mary
  • CASCADE, Mast Cell Degranulation

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