Analyze the steps of the arachidonic acid pathway and describe the implication

Analyze the steps of the arachidonic acid pathway and

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*Analyze the steps of the arachidonic acid pathway and describe the implication for the treatment of inflammationArachidonic acidpathway is a central regulator of inflammatory response. Low pH and bile acids induce cyclooxygenase-2 (COX-2), which is a central enzyme of thearachidonic acidpathway. The COX-2 enzyme catalyzes conversion ofarachidonic acidto different prostaglandins such as prostaglandin E2 (PGE2). PGE2 induces proliferation of Barret’s epithelial cells and its inhibition may slow their growth[36]. PGE2-induced cell proliferation leads to accumulation of replicative errors in premalignant Barrett’s cells. Furthermore, it inhibits tumor surveillance through natural killer cell activity of PGE2. Chronic induction of PGE2 might facilitate accumulation of abnormal cells that have genomic instability and thus inhibition of components ofarachidonic acidpathway probably will inhibit carcinogenesisImmune SystemT-lymphocyte - T cells (thymuscells) - Cell-mediated immunity - some T cells, calledT helper cells, producecytokinesthat direct the immune response, while other T cells, calledcytotoxic T cells, produce toxicgranulesthat contain powerfulenzymeswhich induce the death of pathogen-infected cells. Against fungus, parasites, tumors, transplant rejection.B-lymphocyte - B cells (bone marrow- orbursa-derived cells) – humoral immunity - respond to pathogens by producing large quantities ofantibodieswhich then neutralize foreign objects likebacteriaandviruses.active acquired immunity - vaccinationspassive acquired immunity – breastmilk/placenta (transfer of T cells)*T lymphocytes, B lymphocytes, macrophages, and dendritic cells are involved in acquired immunity.Activation of T cells:Antigen – enters host, macrophage engulfs antigen, antigen expressed on MHC class II, self-antigen – antigens on your own cellsallergen – causes allergic reactionT-lymphocyte cells (functions): T-cytotoxic cells aka CD8 cells aka Killer T’s – kill virus infected cells, tumor cells, and allograft cells (transplant tissue rejection)– induce apoptosisNK Killer cellsT-regulatory cells – slow/stop response once invader is defeated
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  • Fall '15
  • david,mary
  • Histamine, Mast Cell Degranulation

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