The impact of genetic testing on family members may

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The impact of genetic testing on family members may be important depending on context Particularly in cases involving testing for heritable conditions Principle 2: Develop Analytic Frameworks To Reflect the Predictive Nature of Genetic Tests and Incorporate Appropriate Outcomes (4 of 5) Jonas DE, Wilt TJ, Taylor BC, et al. Challenges in and principles for conducting systematic reviews of genetic tests used as predictive indicators. In: Methods guide for medical test reviews. Available at .
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Principle 2: Develop Analytic Frameworks To Reflect the Predictive Nature of Genetic Tests and Incorporate Appropriate Outcomes (5 of 5) Generic Analytic Framework for Evaluating Predictive Genetic Tests When the Impact on Family Members Is Important Jonas DE, Wilt TJ, Taylor BC, et al. Challenges in and principles for conducting systematic reviews of genetic tests used as predictive indicators. In: Methods guide for medical test reviews. Available at .
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Human Genome Epidemiology Network (HuGE Net) HuGE Net is a good supplement to main literature databases (e.g., PubMed ® ). It contains meta-analyses of genetic association studies. The HuGE Navigator can identify all types of available studies related to a genetic test. Gray Literature Package inserts for genetic tests approved by the U.S. Food and Drug Administration (FDA) These inserts include summaries of analytic validity data that were instrumental during FDA approval. They are available on the FDA Web site and on that of the test manufacturers. Genetic test data are also available from the FDA Center for Devices and Radiological Health Web site. Principle 3: Search Databases Appropriate for Genetic Tests (1 of 2) Jonas DE, Wilt TJ, Taylor BC, et al. Challenges in and principles for conducting systematic reviews of genetic tests used as predictive indicators. In: Methods guide for medical test reviews. Available at .
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Gray Literature ( Continued ) American College of Medical Genetics and College of American Pathologists joint external proficiency testing program Useful when no published data on analytic validity exist Gives degree of lab-to-lab variability and sense of reproducibility Professional society conference publications GeneTests Web site sponsored by the Genetic Alliance Association for Molecular Pathology Web site Centers for Disease Control and Prevention programs (e.g., the Genetic Testing Reference Materials Coordination Program) International proficiency testing programs LexisNexis ® database and Cambridge Healthtech Institute Use to identify genetic tests in development for cancer Principle 3: Search Databases Appropriate for Genetic Tests (2 of 2) Jonas DE, Wilt TJ, Taylor BC, et al. Challenges in and principles for conducting systematic reviews of genetic tests used as predictive indicators. In: Methods guide for medical test reviews. Available at .
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