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30 phagocytosis movie

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30 Phagocytosis movie http://www.youtube.com/watch?v=fpOxgAU5fFQ&feature=related http://mcdb.omrf.org/clarkelab/movies_1.html
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31 Adaptive/Specific Immunity Divided into Cell Mediated and Humoral Immunity Cytotoxic T cells B cells Antibodies
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32 M ajor H istoc ompatibility Proteins MHC proteins are present on the surface of body cells and are unique for that particular individual = recognition sites & Ag presentation MHC I MHC II
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33
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34 T cell receptors can only recognize an antigen in the context of MHC proteins
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35 Intracellular vs extracellular pathogen Intracellular Pathogen = MHC I Extracellular pathogen = MHC II
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36 Major Histocompatibility Complex Two kinds of MHC proteins – MHC I presents intracellular antigens – MHC II presents extracellular antigens Extracellular bacteria or virus Antigens endocytosed, added to MHC II in endosome Virus proteins replicating in cell Antigens bind MHC I in endoplasmic reticulum Antigens imported into ER directly from cytoplasm
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37 MHC class I Intracellular Pathogens Infected cells Virus Bacteria Cancer Trigger Tc Cell = CMI MHC class II = Ag Presenting C Extracellular Pathogens Bacteria Parasites Trigger T H cell T H -1 = Tc T H -2 = B Cells
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38 MHC Class I and Class II proteins present antigen CD8 CD4
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39 Major Histocompatibility Complex Movies MHC class II movie http://www.youtube.com/watch?v=_8JMVq7HF2Y MHC class I movie http://www.youtube.com/watch?v=vrFMWyJwGxw&feature=related Movies are in greater detail with lots of other proteins = never mind
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40 Specific Immunity Divided into Cell Mediated and Humoral Immunity Cytotoxic T cells = CD8 B cells Antibodies T helper cells = CD4
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41 T Lymphocyte T Lymphocyte • Helper T cell (CD4) • Cytotoxic T cell (CD8) CD4 T cell with HIV
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42
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