Kmtcqp 08tis 13 a prototype drug a is a

4

KMTC/QP-08/TIS
13. A prototype drug;
14. Drugs with high lipophillicity; 15. Chemical bonding affects drug action in the following ways, except; 16. The products of S-dealkylation are
a) Aldehydes and thiols
b) Aldehydes and sulfones
c) Alcohols and thiols
d) Aldehydes and thioethers
17. Which of the following is not a crucial requirement for a drug to act as an agonist? 18. Hydrogen bonding affects the activity of drug molecules in the following ways except:
19. The common structural feature between β-blockers and isoprenaline is:
Section B.
20. List the desirable properties of a pro-drug (4 marks)
21. Explain why it may be necessary to formulate drugs as pro-drugs with relevant examples
(4 Marks)
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KMTC/QP-08/TIS
22.
a.
The following structure is a 4- phenyl piperidine, explain the phamarcophores in it
which enables it act like an opioid (4 Marks)