A in the presence of phorbol ester which stimulates

This preview shows page 4 out of 4 pages.

(a) in the presence of phorbol ester (which stimulates protein kinase C), then one CS _______same as serotonin e ff ect: potentially bigger CR than the very fi rst one__________ e. (a) in the presence of forskolin (which stimulates adenylyl cyclase) and protein synthesis blockers, then one CS ___adenylyl cyclase will increase the post-synaptic responses, providing some anti-habituation, similar to post-synaptic serotonin e ff ect, but pre-synaptic habituation will still occur ____ f. CS and serotonin together 5 times in the presence of NMDA blocker, then one CS the next day, __big CR increase, as expected for CS-US pairings, since there is no NMDA component in aplysia__ 19. You stab you fi nger on a rose thorn on Valentine’s Day and never forget who gave it to you. Why might you also blame synaptic tagging? (2+2+2 pt) A weaker stimulus might be potentiated by the concurrent stronger stimulus, as in synaptic tagging. Full credit for mentioning CREB activation by the thorn stab and the subsequent CaMKII expression/local activation to make the post-synaptic changes associated with the features of the person persist much longer. 20. If your brain expressed VP16-CREB, might you do BETTER / WORSE on an exam. Why? (3 pt) In theory, even weak factual memories should be strengthened and made more permanent. 21. A mouse with an overactive DNA methylase has weak remote, but strong recent contextual fear memory. Propose a credible hypothesis to explain these observations; there are several. (2+2 pt) Lots of room here for theories: basically, something like di ff erent genes/proteins are involved in potentiating recent memories compared to remote, so what’s good for one can interfere with the other. For example, if remote memory formation relies of a new set of genes, then methylating those might a ff ect remote, but not recent. 4
Image of page 4
You've reached the end of this preview.
  • Spring '16
  • Colgin
  • NMDA

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern