100 mg po bid x 7 d is recommended by the cdc for the

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100 mg PO bid x 7 d is recommended by the CDC for the No dosage reduction needed in renal impairment.Enzyme inducers
treatment of chlamydia, which coexists w/gonorrheacommunity acquired pneumonia Lyme disease2nd line drug for the prevention ortreatment of traveler’s diarrhea and is indicated for the prophylaxis of malaria (CDC)community-acquired MRSAexposure to anthrax inhalationrosaceaperiodontal disease (oral & topical)Legionnaires’ disease(phenobarbital, carbamazepine, phenytoin, rifampin) shorten doxy half life from 16 to 7 hrsofood doesn’t decreaseabsorptionTetracyclinePanmycin; Sumycin & others]. Tetracyclinestreating H. pylori gastritistetracycline cream used for acne Diarrhea may result from the irritative effect of tetracycline but must be distinguished from pseudomembranous colitis.Tigecycline is a tetracycline derivative : use only if you have tetracycline resistant organism.oral or IV*************MACROLIDELipid solublebacteriostatic or bactericidalgood tissue penetrationMOA: inhibit protein synthesis by bacterial ribosomes by penetrating bacterial cell membrane and reversibly binding to the 50S subunit of bacterial ribosomes preventing subsequent protein synthesisH.flu, N.gonorrhoea, mycoplasma [DOC], chlamydia, H. pylori, and organisms causing diphtheria [DOC] and Legionnaires disease [DOC]Neonatal: Chlamydia, Mycoplasma, Ureaplasma, & Bordetella pertussis and as a substitute for penicillin in allergic patientssevere GI upset with abd cramping, N/V/D when given PO or vein irritation w/IV.Suppress bacteria in gutdig toxicitycompete with lincomycins for the 50S microsomes (antagonist)Food may interfere withoral absorptionErythromycinMacrolide(prototype)effective against gram positive, somegram negativeabsorbed from GI but inactivated by gastric juice so usually enteric coated or as acid-resistant esterdiffuses into intracellular fluids (including the fetus) but not the CSFconcentrated in liver, excreted by bileenzyme inhibitorin delayed release capsule, tablet, delay release tablets, and SR tablet. alternative to benzylpenicillin in patients allergic to penicillintopical used for acneDOC in treating GERD in childrenLegionnaires’ diseaseStimulates GI motility diarrhea. Elevated levels may cause sudden death with cardiac causesprolongs cardiac repolarization and is associated with prolonged QT interval & torsades de pointesintense nauseanot effective against anaerobesDon’t give CYP3A inhibitors (diltiazem, verapamil, protease inhibitors & azole antifungal drugs) to pt on erythromycin. Increased cardiac death risk & doubled the AUC
Given 250-500mg q6hrs.

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