Define the zone of polarizing activity use diagram Zone of polarizing activity

Define the zone of polarizing activity use diagram

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10. Define the zone of polarizing activity (use diagram).
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11. What is the role of Shh in anterior-posterior limb axis determination? How is Shh activated in the ZPA (feedback between AER and ZPA)? What is involved in determination/formation of each of the digits? 12. What is the role of BMPs in digitformation? 13. Explain why inserting a bead containing Shh into the anterior region of an early limb bud will result in a mirror image duplication of the limb. 14. What is the signaling pathway responsible for dorsal-ventral limb axis formation? Which germ later is initiating signal transduction events leading to dorsal-ventral limb axis formation? 15. What type of morphogene is Lmx1? What happens if there is a mutation in Lmx1 gene in humans (wt / Lmx1 mutant heterozygotes)
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  • Summer '14
  • Developmental Biology, Mesoderm, Wnt signaling pathway, apical ectodermal ridge, Limb Bud, limb development

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