PoDA spring 2013-1-answers

A drugs initial concentration in the body is 100 mgl

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6. A drug’s initial concentration in the body is 100 mg/L. One hour later it is 75 mg/L, at time t = 2 hrs it is 50 mg/L, at t = 3 hrs it is 25 ml/L, and no drug is left in the patient after four hours. Which of the following statements is TRUE ? A. The drug’s half life is 2 hours B. The drug’s half life is 1 hour C. The drug’s half life will vary depending on how much time has elapsed since it was administered. D. This drug has no half life because it is being eliminated in a first-order fashion. E. This drug has no half life because it is being eliminated in a zero-order fashion.
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7. You determine the area under the curve of a time/drug concentration graph (AUC) after giving the drug orally as well as after administering the drug via intravenous injection. In the first case (oral) the AUC was 70 mg/l•hr while in the second (IV) it was 100 mg/l•hr. What is the bioavailability of this drug after oral administration? 8. Drug “X” is cleared by both the kidney and liver, with a total body clearance of 100 L/hour. If the renal rate constant of elimination is 0.8 hr -1 and the hepatic rate constant of elimination is 1.2 hr -1 what is the volume of distribution of this drug? 9. Which of the following terms best describes log dose-response (LDR) relationships of drug action? 10. Which one of the following statements about this drug binding experiment is CORRECT ? A. In the figure line B represents specific binding, line C represents total binding and line A represents non-specific binding B. In the figure line C represents specific binding, line B represents total binding and line A represents non-specific binding C. In the figure line A represents specific binding, line B represents total binding and line C represents non-specific binding D. In the figure line B represents specific binding, line A represents total binding and line C represents non-specific binding E. In the figure line C represents specific binding, line A represents total binding and line B represents non-specific binding
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