Contains all electron transport chain machinery

Info icon This preview shows pages 16–23. Sign up to view the full content.

View Full Document Right Arrow Icon
Contains all electron transport chain machinery Contains all ATP synthesis machinery Intermembrane space Complex shape (follows contours of inner membrane pH ~7 Matrix all enzymes required for Krebs cycle Hold mitochondrial genome, ribosomes, enzymes for mitochondrial division pH ~8
Image of page 16

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Signal Sequences
Image of page 17
Mitochondrial Protein Transport Players Hsc70 Chaperones Outer membrane Translocon Outer membrane receptors - Tom 20/22 or Tom 70/22 Outer membrane channel- Tom 40 Inner membrane Translocon Inner membrane channel- Tim 23/17 Matrix Proteases
Image of page 18

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Juxtaposition of Inner and Outer Membranes at Transport Sites
Image of page 19
Mitochondrial Protein Transport Cytosolic Hsc70 keeps precursor Protein in partially unfolded state Tom20/22 Receptor recognized matrix-targeting sequence Transfer of Precursor through Tom40 channel Passes through Tim23/17 channel Matrix Hsc70 helps pull precursor through channel Matrix protease cleaves off signal sequence
Image of page 20

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Transport of Mitochondrial Membrane Proteins
Image of page 21
Stop-Transfer Players Tom20/22 Tom40 Tim23/17 Tim44 Hsc70 Matrix Protease
Image of page 22

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Stop-Transfer Process same as with Matrix- targeted protein BUT Internal Stop-Transfer sequence recognized by Tim23/17 channel Precursor is transferred into the inner membrane
Image of page 23
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern