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Contains all electron transport chain machinery

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Contains all electron transport chain machinery Contains all ATP synthesis machinery Intermembrane space Complex shape (follows contours of inner membrane pH ~7 Matrix all enzymes required for Krebs cycle Hold mitochondrial genome, ribosomes, enzymes for mitochondrial division pH ~8
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Signal Sequences
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Mitochondrial Protein Transport Players Hsc70 Chaperones Outer membrane Translocon Outer membrane receptors - Tom 20/22 or Tom 70/22 Outer membrane channel- Tom 40 Inner membrane Translocon Inner membrane channel- Tim 23/17 Matrix Proteases
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Juxtaposition of Inner and Outer Membranes at Transport Sites
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Mitochondrial Protein Transport Cytosolic Hsc70 keeps precursor Protein in partially unfolded state Tom20/22 Receptor recognized matrix-targeting sequence Transfer of Precursor through Tom40 channel Passes through Tim23/17 channel Matrix Hsc70 helps pull precursor through channel Matrix protease cleaves off signal sequence
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Transport of Mitochondrial Membrane Proteins
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Stop-Transfer Players Tom20/22 Tom40 Tim23/17 Tim44 Hsc70 Matrix Protease
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Stop-Transfer Process same as with Matrix- targeted protein BUT Internal Stop-Transfer sequence recognized by Tim23/17 channel Precursor is transferred into the inner membrane
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