Dimeticone A wide range of dimeticone-containing products for the treatment of head lice are available, some of which are classified as medical devices. Dimeticone is generally regarded as a relatively nontoxic and nonirritant material. In pharmaceutical formulations it may be used in oral and topical preparations. Dimeticones are also used extensively in cosmetic formulations and in certain food applications (5). Available through NICE Evidence Search at 1
Medicines Q&As Solutions containing 4 to 95% dimeticone are used in the treatment of head lice, and act by physically coating the lice and disrupting their water management (6). Recent data on dimeticone 4% showed similar efficacy to previously published studies, around 70%. No resistance towards dimeticone has been documented (2). Dimeticone is likely to be less irritant than other chemical treatments and it is not absorbed transdermally (7). A European expert source considers the use of oral dimethicone, as an anti-flatulent, to be safe and compatible with breast feeding (8). No studies on the passage of dimethicone into human breast milk could be located. Isopropyl myristate/cyclomethicone (Full Marks Solution ® ) Full Marks Solution ® is classified as a medical device as such does not have an associated SPC. The manufacturer states that as the product has not been tested on pregnant or breastfeeding women they are unable to advise if it will be suitable or not (9). Isopropyl myristate is absorbed fairly readily by the skin and is used as a basis for relatively nongreasy emollient ointments and creams. It is widely used in cosmetics and topical pharmaceutical formulations, and is generally regarded as a nontoxic and nonirritant material. Therapeutically, isopropyl myristate 50% has been shown to be an effective pediculicide for the control of head lice (5). Cyclomethicone is a cyclic silicone fluid that is generally regarded as a relatively nontoxic and nonirritant material. Although it has been used in oral pharmaceutical applications, cyclomethicone is mainly used in topical pharmaceutical formulations. It is also widely used in cosmetics. Studies of the animal and human toxicology of cyclomethicone suggest that it is nonirritant and not absorbed through the skin (5). No studies on the passage of isopropyl myristate or cyclomethicone into human breast milk could be located. Malathion Derbac M Liquid ® (malathion 0.5% w / w ) is licensed for the eradication of head lice, pubic lice and their eggs and the treatment of scabies. The SPC for Derbac M Liquid states that there are no known effects in pregnancy and lactation. However, as with all medicines, caution with use is advised (10). Percutaneous absorption of malathion is limited. In vitro studies in isolated skin suggest the percutaneous absorption of malathion from a topically applied aqueous ethanolic solution to be approximately 10% (11). Similarly in a study of human volunteers, approximately 4% of the dose applied to the skin was absorbed and this proportion did not change with repeated daily application to the same site for 8 days (12).
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- Summer '19
- Head louse, Pediculosis, Body louse, Dimeticone